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Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation

Mutations in the granulin (GRN) gene, resulting in haploinsufficiency of the progranulin (PGRN) protein, are a leading cause of frontotemporal lobar degeneration (FTLD) and PGRN polymorphisms are associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD). PGRN is a key regulator of microg...

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Detalles Bibliográficos
Autores principales:	Du, Huan, Yang, Cha, Nana, Alissa L., Seeley, William W., Smolka, Marcus, Hu, Fenghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104136/ https://www.ncbi.nlm.nih.gov/pubmed/37066328 http://dx.doi.org/10.1101/2023.04.06.535844

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