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Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review

BACKGROUND: Cancer incidence and mortality are increasing rapidly worldwide, necessitating further investigation into developing and optimizing emergent cancer therapies. Oncolytic viruses such as vesicular stomatitis virus encoding interferon β (VSV-IFNβ) have attracted considerable attention, as t...

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Autores principales: Moglan, Abdulaziz Molham, Albaradie, Omar A., Alsayegh, Fares Fayez, Alharbi, Hussam Mohsen, Samman, Yahya Marwan, Jalal, Mohammed M., Saeedi, Nizar H., Mahmoud, Ahmad Bakur, Alkayyal, Almohanad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104167/
https://www.ncbi.nlm.nih.gov/pubmed/37063914
http://dx.doi.org/10.3389/fimmu.2023.1085940
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author Moglan, Abdulaziz Molham
Albaradie, Omar A.
Alsayegh, Fares Fayez
Alharbi, Hussam Mohsen
Samman, Yahya Marwan
Jalal, Mohammed M.
Saeedi, Nizar H.
Mahmoud, Ahmad Bakur
Alkayyal, Almohanad A.
author_facet Moglan, Abdulaziz Molham
Albaradie, Omar A.
Alsayegh, Fares Fayez
Alharbi, Hussam Mohsen
Samman, Yahya Marwan
Jalal, Mohammed M.
Saeedi, Nizar H.
Mahmoud, Ahmad Bakur
Alkayyal, Almohanad A.
author_sort Moglan, Abdulaziz Molham
collection PubMed
description BACKGROUND: Cancer incidence and mortality are increasing rapidly worldwide, necessitating further investigation into developing and optimizing emergent cancer therapies. Oncolytic viruses such as vesicular stomatitis virus encoding interferon β (VSV-IFNβ) have attracted considerable attention, as they offer great efficacy and safety profiles. This systematic review aimed to determine and compare the efficacy profile between VSV-IFNβ and non-treatment controls in preclinical cancer models. METHODOLOGY: The Embase and Medline databases were systematically searched for relevant studies using related key terms and Medical Subject Headings (MeSH). Titles, abstracts, and full texts were screened, and data from eligible articles were extracted by two groups independently and in duplicate (two reviewers per group). Disagreements were resolved by a fifth independent reviewer. The included articles were all preclinical (translational) in vivo English studies that investigated and compared the efficacy profile between VSV-IFNβ and non-treatment controls in animal models. The risk of bias among the studies was assessed by two reviewers independently and in duplicate using SYRCLE’s risk-of-bias tool for animal studies; disparities were addressed by a third independent reviewer. RESULTS: After employing relevant MeSH and key terms, we identified 1598 articles. A total of 87 articles were either duplicates or conference proceedings and were thus excluded. Following title and abstract screening, 37 articles were included in the full-text assessment. Finally, 14 studies met the eligibility criteria. Forty-two experiments from the included studies examined the potential efficacy of VSV-IFNβ through different routes of administration, including intratumoral, intraperitoneal, and intravenous routes. Thirty-seven experiments reported positive outcomes. Meanwhile, five experiments reported negative outcomes, three and two of which examined intratumoral and intravenous VSV-IFNβ administration, respectively. CONCLUSION: Although the majority of the included studies support the promising potential of VSV-IFNβ as an oncolytic virus, further research is necessary to ensure a safe and efficacious profile to translate its application into clinical trials. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022335418.
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spelling pubmed-101041672023-04-15 Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review Moglan, Abdulaziz Molham Albaradie, Omar A. Alsayegh, Fares Fayez Alharbi, Hussam Mohsen Samman, Yahya Marwan Jalal, Mohammed M. Saeedi, Nizar H. Mahmoud, Ahmad Bakur Alkayyal, Almohanad A. Front Immunol Immunology BACKGROUND: Cancer incidence and mortality are increasing rapidly worldwide, necessitating further investigation into developing and optimizing emergent cancer therapies. Oncolytic viruses such as vesicular stomatitis virus encoding interferon β (VSV-IFNβ) have attracted considerable attention, as they offer great efficacy and safety profiles. This systematic review aimed to determine and compare the efficacy profile between VSV-IFNβ and non-treatment controls in preclinical cancer models. METHODOLOGY: The Embase and Medline databases were systematically searched for relevant studies using related key terms and Medical Subject Headings (MeSH). Titles, abstracts, and full texts were screened, and data from eligible articles were extracted by two groups independently and in duplicate (two reviewers per group). Disagreements were resolved by a fifth independent reviewer. The included articles were all preclinical (translational) in vivo English studies that investigated and compared the efficacy profile between VSV-IFNβ and non-treatment controls in animal models. The risk of bias among the studies was assessed by two reviewers independently and in duplicate using SYRCLE’s risk-of-bias tool for animal studies; disparities were addressed by a third independent reviewer. RESULTS: After employing relevant MeSH and key terms, we identified 1598 articles. A total of 87 articles were either duplicates or conference proceedings and were thus excluded. Following title and abstract screening, 37 articles were included in the full-text assessment. Finally, 14 studies met the eligibility criteria. Forty-two experiments from the included studies examined the potential efficacy of VSV-IFNβ through different routes of administration, including intratumoral, intraperitoneal, and intravenous routes. Thirty-seven experiments reported positive outcomes. Meanwhile, five experiments reported negative outcomes, three and two of which examined intratumoral and intravenous VSV-IFNβ administration, respectively. CONCLUSION: Although the majority of the included studies support the promising potential of VSV-IFNβ as an oncolytic virus, further research is necessary to ensure a safe and efficacious profile to translate its application into clinical trials. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022335418. Frontiers Media S.A. 2023-03-31 /pmc/articles/PMC10104167/ /pubmed/37063914 http://dx.doi.org/10.3389/fimmu.2023.1085940 Text en Copyright © 2023 Moglan, Albaradie, Alsayegh, Alharbi, Samman, Jalal, Saeedi, Mahmoud and Alkayyal https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Moglan, Abdulaziz Molham
Albaradie, Omar A.
Alsayegh, Fares Fayez
Alharbi, Hussam Mohsen
Samman, Yahya Marwan
Jalal, Mohammed M.
Saeedi, Nizar H.
Mahmoud, Ahmad Bakur
Alkayyal, Almohanad A.
Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review
title Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review
title_full Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review
title_fullStr Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review
title_full_unstemmed Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review
title_short Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review
title_sort preclinical efficacy of oncolytic vsv-ifnβ in treating cancer: a systematic review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104167/
https://www.ncbi.nlm.nih.gov/pubmed/37063914
http://dx.doi.org/10.3389/fimmu.2023.1085940
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