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Oral TGF-βR1 inhibitor Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity

Osteosarcoma (OS) is an aggressive malignant bone cancer, with refractory and metastatic disease remaining a significant challenge. Transforming growth factor-β1 (TGF-β) is a potent immune suppressive cytokine in OS and the TGF-β is increased in the sera of OS patients and this increase is associate...

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Detalles Bibliográficos
Autores principales:	Choi, Sung Hee, Myers, Jay, Tomchuck, Suzanne, Bonner, Melissa, Eid, Saada, Kingsley, Daniel, VanHeyst, Kristen, Kim, Seong-Jin, Kim, Byung-Gyu, Huang, Alex Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104208/ https://www.ncbi.nlm.nih.gov/pubmed/37066414 http://dx.doi.org/10.21203/rs.3.rs-2709282/v1

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