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Validation of a polygenic risk score for Frailty in the Lothian Birth Cohort and English Longitudinal Study of Ageing

Frailty is a complex trait. Twin studies and a high-powered Genome Wide Association Study (GWAS) conducted in the UK Biobank have demonstrated a strong genetic basis of frailty. The present study utilized summary statistics from this GWAS to create and test the predictive power of frailty polygenic...

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Detalles Bibliográficos
Autores principales:	Flint, J P, Welstead, M, Cox, S R, Russ, T C, Marshall, A, Luciano, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104224/ https://www.ncbi.nlm.nih.gov/pubmed/37066324 http://dx.doi.org/10.1101/2023.04.03.23288064

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