Aging gene signature of IL-7 receptor alpha low effector memory CD8(+) T cells is associated with neurocognitive functioning in Alzheimer’s disease

CD45RA(+) effector memory (EM) CD8(+) T cell expansion was reported in Alzheimer’s disease (AD). Such cells are IL-7 receptor alpha (IL-7Rα)(low) EM CD8(+) T cells, which expand with age and have a unique aging gene signature (i.e., IL-7Rα(low) aging genes). Here we investigated whether IL-7Rα(low)...

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Detalles Bibliográficos
Autores principales: Young, Juan, Park, Hong-Jai, Kim, Minhyung, Par-Young, Jennefer, Bartlett, Hugh, Kim, Hye Sun, Unlu, Serhan, Osmani, Lais, Shin, Min Sun, Bucala, Richard, van Dyck, Christopher, Allore, Heather, Mecca, Adam, You, Sungyong, Kang, Insoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104241/
https://www.ncbi.nlm.nih.gov/pubmed/37066364
http://dx.doi.org/10.21203/rs.3.rs-2736771/v1

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