Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report

A 44-year-old female patient with multiple sclerosis (MS) treated with ocrelizumab was hospitalized with SARS-CoV-2 pneumonia three times over the course of five months, eventually expiring. Viral sequencing of samples from her first and last admissions suggests a single persistent SARS-CoV-2 infect...

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Autores principales: Ambadapoodi, Raghava S., Arnold, Forest W., Chariker, Julia H., Glynn, Alex, Lauer, William, Marimuthu, Subathra, Rouchka, Eric C., Smith, Melissa L., Wolf, Leslie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104259/
https://www.ncbi.nlm.nih.gov/pubmed/37066424
http://dx.doi.org/10.21203/rs.3.rs-2768759/v1
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author Ambadapoodi, Raghava S.
Arnold, Forest W.
Chariker, Julia H.
Glynn, Alex
Lauer, William
Marimuthu, Subathra
Rouchka, Eric C.
Smith, Melissa L.
Wolf, Leslie A.
author_facet Ambadapoodi, Raghava S.
Arnold, Forest W.
Chariker, Julia H.
Glynn, Alex
Lauer, William
Marimuthu, Subathra
Rouchka, Eric C.
Smith, Melissa L.
Wolf, Leslie A.
author_sort Ambadapoodi, Raghava S.
collection PubMed
description A 44-year-old female patient with multiple sclerosis (MS) treated with ocrelizumab was hospitalized with SARS-CoV-2 pneumonia three times over the course of five months, eventually expiring. Viral sequencing of samples from her first and last admissions suggests a single persistent SARS-CoV-2 infection. We hypothesize that her immunocompromised state, due to MS treatment with an immunosuppressive monoclonal antibody, prevented her from achieving viral clearance.
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spelling pubmed-101042592023-04-15 Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report Ambadapoodi, Raghava S. Arnold, Forest W. Chariker, Julia H. Glynn, Alex Lauer, William Marimuthu, Subathra Rouchka, Eric C. Smith, Melissa L. Wolf, Leslie A. Res Sq Article A 44-year-old female patient with multiple sclerosis (MS) treated with ocrelizumab was hospitalized with SARS-CoV-2 pneumonia three times over the course of five months, eventually expiring. Viral sequencing of samples from her first and last admissions suggests a single persistent SARS-CoV-2 infection. We hypothesize that her immunocompromised state, due to MS treatment with an immunosuppressive monoclonal antibody, prevented her from achieving viral clearance. American Journal Experts 2023-04-04 /pmc/articles/PMC10104259/ /pubmed/37066424 http://dx.doi.org/10.21203/rs.3.rs-2768759/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Ambadapoodi, Raghava S.
Arnold, Forest W.
Chariker, Julia H.
Glynn, Alex
Lauer, William
Marimuthu, Subathra
Rouchka, Eric C.
Smith, Melissa L.
Wolf, Leslie A.
Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report
title Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report
title_full Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report
title_fullStr Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report
title_full_unstemmed Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report
title_short Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report
title_sort persistent sars-cov-2 infection in a multiple sclerosis patient on ocrelizumab: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104259/
https://www.ncbi.nlm.nih.gov/pubmed/37066424
http://dx.doi.org/10.21203/rs.3.rs-2768759/v1
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