Analytical validation of a multi-cancer early detection test with cancer signal origin using a cell-free DNA–based targeted methylation assay

The analytical validation is reported for a targeted methylation-based cell-free DNA multi-cancer early detection test designed to detect cancer and predict the cancer signal origin (tissue of origin). A machine-learning classifier was used to analyze the methylation patterns of >10(5) genomic ta...

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Detalles Bibliográficos
Autores principales: Alexander, Gregory E., Lin, Wendy, Ortega, Fabian E., Ramaiah, Madhuvanthi, Jung, Byoungsok, Ji, Lijuan, Revenkova, Ekaterina, Shah, Payal, Croisetiere, Christian, Berman, Jennifer R., Eubank, Lane, Naik, Gunjan, Brooks, Jacqueline, Mich, Andrea, Shojaee, Seyedmehdi, Ronaghi, Neda, Chawla, Hemanshi, Hou, Xinyi, Liu, Qinwen, Yakym, Christopher-James A. V., Moradi, Patriss Wais, Halks-Miller, Meredith, Aravanis, Alexander M., Parpart-Li, Sonya, Hunkapiller, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104288/
https://www.ncbi.nlm.nih.gov/pubmed/37058491
http://dx.doi.org/10.1371/journal.pone.0283001

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