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“Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”

This study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during the first pandemic wave. We performed a prospective, observational, multicenter study of confirmed COVID-19 patients admitted to 19 intensive care units (ICUs) in Catalonia (Spain). D...

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Autores principales: Sánchez, Arsenio De La Vega, Pérez, Ana Navas, Pérez-Carrasco, Marcos, Sonet, María Torrens, Buendia, Yolanda Diaz, Ballujera, Patricia Ortiz, López, Miguel Rodríguez, Riera, Joan Sabater, Olmo-Isasmendi, Aitor, Torra, Ester Vendrell, García-Pumarino, María Álvarez, Villamayor, Mercedes Ibarz, Catalán Ibars, Rosa María, Zelaya, Iban Oliva, Chica, Javier Pardos, Anglès, Conxita Rovira, Tomasa-Irriguible, Teresa M., Serra, Anna Baró, Casanova, Edward J., De Molina, Francisco J. González
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104297/
https://www.ncbi.nlm.nih.gov/pubmed/37058544
http://dx.doi.org/10.1371/journal.pone.0284248
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author Sánchez, Arsenio De La Vega
Pérez, Ana Navas
Pérez-Carrasco, Marcos
Sonet, María Torrens
Buendia, Yolanda Diaz
Ballujera, Patricia Ortiz
López, Miguel Rodríguez
Riera, Joan Sabater
Olmo-Isasmendi, Aitor
Torra, Ester Vendrell
García-Pumarino, María Álvarez
Villamayor, Mercedes Ibarz
Catalán Ibars, Rosa María
Zelaya, Iban Oliva
Chica, Javier Pardos
Anglès, Conxita Rovira
Tomasa-Irriguible, Teresa M.
Serra, Anna Baró
Casanova, Edward J.
De Molina, Francisco J. González
author_facet Sánchez, Arsenio De La Vega
Pérez, Ana Navas
Pérez-Carrasco, Marcos
Sonet, María Torrens
Buendia, Yolanda Diaz
Ballujera, Patricia Ortiz
López, Miguel Rodríguez
Riera, Joan Sabater
Olmo-Isasmendi, Aitor
Torra, Ester Vendrell
García-Pumarino, María Álvarez
Villamayor, Mercedes Ibarz
Catalán Ibars, Rosa María
Zelaya, Iban Oliva
Chica, Javier Pardos
Anglès, Conxita Rovira
Tomasa-Irriguible, Teresa M.
Serra, Anna Baró
Casanova, Edward J.
De Molina, Francisco J. González
author_sort Sánchez, Arsenio De La Vega
collection PubMed
description This study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during the first pandemic wave. We performed a prospective, observational, multicenter study of confirmed COVID-19 patients admitted to 19 intensive care units (ICUs) in Catalonia (Spain). Data regarding demographics, comorbidities, drug and medical treatment, physiological and laboratory results, AKI development, need for renal replacement therapy (RRT) and clinical outcomes were collected. Descriptive statistics and logistic regression analysis for AKI development and mortality were used. A total of 1,642 patients were enrolled (mean age 63 (15.95) years, 67.5% male). Mechanical ventilation (MV) was required for 80.8% and 64.4% of these patients, who were in prone position, while 67.7% received vasopressors. AKI at ICU admission was 28.4% and increased to 40.1% during ICU stay. A total of 172 (10.9%) patients required RRT, which represents 27.8% of the patients who developed AKI. AKI was more frequent in severe acute respiratory distress syndrome (ARDS) ARDS patients (68% vs 53.6%, p<0.001) and in MV patients (91.9% vs 77.7%, p<0.001), who required the prone position more frequently (74.8 vs 61%, p<0.001) and developed more infections. ICU and hospital mortality were increased in AKI patients (48.2% vs 17.7% and 51.1% vs 19%, p <0.001) respectively). AKI was an independent factor associated with mortality (IC 1.587–3.190). Mortality was higher in AKI patients who required RRT (55.8% vs 48.2%, p <0.04). Conclusions There is a high incidence of AKI in critically ill patients with COVID-19 disease and it is associated with higher mortality, increased organ failure, nosocomial infections and prolonged ICU stay.
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spelling pubmed-101042972023-04-15 “Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia” Sánchez, Arsenio De La Vega Pérez, Ana Navas Pérez-Carrasco, Marcos Sonet, María Torrens Buendia, Yolanda Diaz Ballujera, Patricia Ortiz López, Miguel Rodríguez Riera, Joan Sabater Olmo-Isasmendi, Aitor Torra, Ester Vendrell García-Pumarino, María Álvarez Villamayor, Mercedes Ibarz Catalán Ibars, Rosa María Zelaya, Iban Oliva Chica, Javier Pardos Anglès, Conxita Rovira Tomasa-Irriguible, Teresa M. Serra, Anna Baró Casanova, Edward J. De Molina, Francisco J. González PLoS One Research Article This study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during the first pandemic wave. We performed a prospective, observational, multicenter study of confirmed COVID-19 patients admitted to 19 intensive care units (ICUs) in Catalonia (Spain). Data regarding demographics, comorbidities, drug and medical treatment, physiological and laboratory results, AKI development, need for renal replacement therapy (RRT) and clinical outcomes were collected. Descriptive statistics and logistic regression analysis for AKI development and mortality were used. A total of 1,642 patients were enrolled (mean age 63 (15.95) years, 67.5% male). Mechanical ventilation (MV) was required for 80.8% and 64.4% of these patients, who were in prone position, while 67.7% received vasopressors. AKI at ICU admission was 28.4% and increased to 40.1% during ICU stay. A total of 172 (10.9%) patients required RRT, which represents 27.8% of the patients who developed AKI. AKI was more frequent in severe acute respiratory distress syndrome (ARDS) ARDS patients (68% vs 53.6%, p<0.001) and in MV patients (91.9% vs 77.7%, p<0.001), who required the prone position more frequently (74.8 vs 61%, p<0.001) and developed more infections. ICU and hospital mortality were increased in AKI patients (48.2% vs 17.7% and 51.1% vs 19%, p <0.001) respectively). AKI was an independent factor associated with mortality (IC 1.587–3.190). Mortality was higher in AKI patients who required RRT (55.8% vs 48.2%, p <0.04). Conclusions There is a high incidence of AKI in critically ill patients with COVID-19 disease and it is associated with higher mortality, increased organ failure, nosocomial infections and prolonged ICU stay. Public Library of Science 2023-04-14 /pmc/articles/PMC10104297/ /pubmed/37058544 http://dx.doi.org/10.1371/journal.pone.0284248 Text en © 2023 Sánchez et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sánchez, Arsenio De La Vega
Pérez, Ana Navas
Pérez-Carrasco, Marcos
Sonet, María Torrens
Buendia, Yolanda Diaz
Ballujera, Patricia Ortiz
López, Miguel Rodríguez
Riera, Joan Sabater
Olmo-Isasmendi, Aitor
Torra, Ester Vendrell
García-Pumarino, María Álvarez
Villamayor, Mercedes Ibarz
Catalán Ibars, Rosa María
Zelaya, Iban Oliva
Chica, Javier Pardos
Anglès, Conxita Rovira
Tomasa-Irriguible, Teresa M.
Serra, Anna Baró
Casanova, Edward J.
De Molina, Francisco J. González
“Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”
title “Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”
title_full “Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”
title_fullStr “Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”
title_full_unstemmed “Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”
title_short “Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”
title_sort “acute kidney injury in critically ill patients with covid–19: the akicov multicenter study in catalonia”
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104297/
https://www.ncbi.nlm.nih.gov/pubmed/37058544
http://dx.doi.org/10.1371/journal.pone.0284248
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