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Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases

Myocarditis refers to inflammation of the heart muscle and may occur individually or together with pericarditis, which refers to inflammation of the saclike tissue layer that surrounds the heart. They may have infectious or non-infectious etiologies. Campylobacter jejuni, a major cause of gastroente...

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Autores principales: Mohamed Jiffry, Mohamed Zakee, Okam, Nkechi A, Vargas, Jonathan, Adekunle, Faith A, Pagan, Stephanie C, Khowaja, Faisal, Ahmed-Khan, Mohammad A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104424/
https://www.ncbi.nlm.nih.gov/pubmed/37065376
http://dx.doi.org/10.7759/cureus.36171
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author Mohamed Jiffry, Mohamed Zakee
Okam, Nkechi A
Vargas, Jonathan
Adekunle, Faith A
Pagan, Stephanie C
Khowaja, Faisal
Ahmed-Khan, Mohammad A
author_facet Mohamed Jiffry, Mohamed Zakee
Okam, Nkechi A
Vargas, Jonathan
Adekunle, Faith A
Pagan, Stephanie C
Khowaja, Faisal
Ahmed-Khan, Mohammad A
author_sort Mohamed Jiffry, Mohamed Zakee
collection PubMed
description Myocarditis refers to inflammation of the heart muscle and may occur individually or together with pericarditis, which refers to inflammation of the saclike tissue layer that surrounds the heart. They may have infectious or non-infectious etiologies. Campylobacter jejuni, a major cause of gastroenteritis worldwide, may also cause myocarditis in rare situations. We present two cases highlighting this rare complication of diarrheal disease caused by Campylobacter jejuni infection and subsequent development of myocarditis. Both patients presented with chest pain and multiple episodes of watery diarrhea, with initial EKGs showing ST segment changes, as well as elevated inflammatory markers and elevated troponins. GI panels for both patients were positive for Campylobacter jejuni. Based on their presentations and investigative findings, they were diagnosed with myocarditis secondary to Campylobacter infection, and their symptoms subsided with appropriate management. It is unclear if the myocardial damage, in this case, is a direct effect of the toxin on cardiac myocytes or secondary to an immunologic phenomenon. Regardless, Campylobacter jejuni-associated myocarditis remains a rare phenomenon and needs to be considered in the differential of patients presenting with concurrent chest pain and diarrheal symptoms.
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spelling pubmed-101044242023-04-15 Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases Mohamed Jiffry, Mohamed Zakee Okam, Nkechi A Vargas, Jonathan Adekunle, Faith A Pagan, Stephanie C Khowaja, Faisal Ahmed-Khan, Mohammad A Cureus Cardiology Myocarditis refers to inflammation of the heart muscle and may occur individually or together with pericarditis, which refers to inflammation of the saclike tissue layer that surrounds the heart. They may have infectious or non-infectious etiologies. Campylobacter jejuni, a major cause of gastroenteritis worldwide, may also cause myocarditis in rare situations. We present two cases highlighting this rare complication of diarrheal disease caused by Campylobacter jejuni infection and subsequent development of myocarditis. Both patients presented with chest pain and multiple episodes of watery diarrhea, with initial EKGs showing ST segment changes, as well as elevated inflammatory markers and elevated troponins. GI panels for both patients were positive for Campylobacter jejuni. Based on their presentations and investigative findings, they were diagnosed with myocarditis secondary to Campylobacter infection, and their symptoms subsided with appropriate management. It is unclear if the myocardial damage, in this case, is a direct effect of the toxin on cardiac myocytes or secondary to an immunologic phenomenon. Regardless, Campylobacter jejuni-associated myocarditis remains a rare phenomenon and needs to be considered in the differential of patients presenting with concurrent chest pain and diarrheal symptoms. Cureus 2023-03-15 /pmc/articles/PMC10104424/ /pubmed/37065376 http://dx.doi.org/10.7759/cureus.36171 Text en Copyright © 2023, Mohamed Jiffry et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Mohamed Jiffry, Mohamed Zakee
Okam, Nkechi A
Vargas, Jonathan
Adekunle, Faith A
Pagan, Stephanie C
Khowaja, Faisal
Ahmed-Khan, Mohammad A
Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases
title Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases
title_full Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases
title_fullStr Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases
title_full_unstemmed Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases
title_short Myocarditis as a Complication of Campylobacter jejuni-Associated Enterocolitis: A Report of Two Cases
title_sort myocarditis as a complication of campylobacter jejuni-associated enterocolitis: a report of two cases
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104424/
https://www.ncbi.nlm.nih.gov/pubmed/37065376
http://dx.doi.org/10.7759/cureus.36171
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