Cargando…

Evaluation of LFA-1 Peptide-Methotrexate Conjugates in Modulating Endothelial Cell Inflammation and Cytokine Regulation

Interactions between vascular endothelial cells and inflammatory leukocytes are intermediated via cell adhesion molecules and they become one of the key events for vascular cell injury and development of atherosclerosis. This study evaluated the effects of MTX-peptide conjugates as anti-inflammatory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yusuf-Makagiansar, Helena, Yakovleva, Tatyana V., Weldele, Meagan, Mahadik, Rucha, Siahaan, Teruna J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104456/ https://www.ncbi.nlm.nih.gov/pubmed/37063234 http://dx.doi.org/10.18103/mra.v11i2.3534

Ejemplares similares

Immune Modulation by Antigenic Peptides and Antigenic Peptide Conjugates for Treatment of Multiple Sclerosis
por: Mahadik, Rucha, et al.
Publicado: (2022)

Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes
por: Manikwar, Prakash, et al.
Publicado: (2011)

Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides
por: Ulapane, Kavisha R., et al.
Publicado: (2019)

Immune Tolerance Induction against Experimental Autoimmune Encephalomyelitis (EAE) Using A New PLP-B7AP Conjugate that Simultaneously Targets B7/CD28 Costimulatory Signal and TCR/MHC-II Signal
por: Badawi, Ahmed H, et al.
Publicado: (2014)

Modulation of Blood–Brain Barrier Permeability in Mice Using Synthetic E-Cadherin Peptide
por: On, Ngoc H., et al.
Publicado: (2014)

Structural Design and Synthesis of Novel Cyclic Peptide Inhibitors Targeting Mycobacterium tuberculosis Transcription
por: Stephanie, Filia, et al.
Publicado: (2022)

Blocking LFA-1 Aggravates Cardiac Inflammation in Experimental Autoimmune Myocarditis
por: Weckbach, Ludwig T., et al.
Publicado: (2019)

M. tuberculosis Transcription Machinery: A Review on the Mycobacterial RNA Polymerase and Drug Discovery Efforts
por: Stephanie, Filia, et al.
Publicado: (2022)

Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated with LFA-1-deficient mutants
Publicado: (1989)

ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway
Publicado: (1993)

Suppression of LFA-1 Expression by Spermine Is Associated with Enhanced Methylation of ITGAL, the LFA-1 Promoter Area
por: Kano, Yoshihiko, et al.
Publicado: (2013)

Neutrophil arrest by LFA-1 activation
por: Lefort, Craig T., et al.
Publicado: (2012)

LFA-1 in T Cell Migration and Differentiation
por: Walling, Brandon L., et al.
Publicado: (2018)

Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration
por: Shaw, Sunil K., et al.
Publicado: (2004)

Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments
por: Askanase, Anca, et al.
Publicado: (2015)

Role of LFA-1 and ICAM-1 in Cancer
por: Reina, Manuel, et al.
Publicado: (2017)

Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease
por: Li, Wenjie, et al.
Publicado: (2020)

Anticancer Conjugates and Cocktails Based on Methotrexate and Nucleoside Synergism
por: Vortherms, Anthony R., et al.
Publicado: (2009)

Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection using MRI, NIRF, and Mass Spectrometry
por: Ulapane, Kavisha R., et al.
Publicado: (2017)

Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3
Publicado: (1991)

Signaling by lymphocyte function-associated antigen 1 (LFA-1) in B cells: enhanced antigen presentation after stimulation through LFA-1
Publicado: (1992)

Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1
por: Guo, Huaijian, et al.
Publicado: (2016)

Understanding the Role of LFA-1 in Leukocyte Adhesion Deficiency Type I (LAD I): Moving towards Inflammation?
por: Fekadu, Julia, et al.
Publicado: (2022)

Use of biotin targeted methotrexate–human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy
por: Taheri, Azade, et al.
Publicado: (2011)

Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: a combinational approach for enhanced delivery of nanoparticles
por: Norouzi, Mohammad, et al.
Publicado: (2020)

HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)
por: Hioe, Catarina E., et al.
Publicado: (2011)

Selectin-Targeting Peptide–Glycosaminoglycan Conjugates Modulate Neutrophil–Endothelial Interactions
por: Wodicka, James R., et al.
Publicado: (2018)

Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment
por: Xu, Dan, et al.
Publicado: (2018)

Correction: Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1
por: Guo, Huaijian, et al.
Publicado: (2016)

Divalent cation regulation of the function of the leukocyte integrin LFA-1
Publicado: (1992)

Importance of integrin LFA-1 deactivation for the generation of immune responses
por: Semmrich, Monika, et al.
Publicado: (2005)

Conversion of Failed Hip Hemiarthroplasty to Low Friction Arthroplasty (LFA)
por: Bayam, Levent, et al.
Publicado: (2019)

Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion
por: Howlader, Md. Amran, et al.
Publicado: (2019)

LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation
por: Shi, Huiping, et al.
Publicado: (2023)

Differential effects of leflunomide and methotrexate on cytokine production in RA
por: Kraan, MC, et al.
Publicado: (2003)

Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission
Publicado: (1991)

The Use of Lymphocyte Function–Associated Antigen (Lfa)-1–Deficient Mice to Determine the Role of Lfa-1, Mac-1, and α4 Integrin in the Inflammatory Response of Neutrophils
por: Henderson, Robert B., et al.
Publicado: (2001)

Endothelial cells augment T cell interleukin 2 production by a contact- dependent mechanism involving CD2/LFA-3 interaction
Publicado: (1990)

Bone-targeted methotrexate–alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo
por: Xie, Zi’ang, et al.
Publicado: (2018)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_in3tmc6qvo0sbhj5nmsq7jr7t2