A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon

Hundreds of pathogenic variants of mitochondrial DNA (mtDNA) have been reported to cause mitochondrial diseases, which still lack effective treatments. It is a huge challenge to install these mutations one by one. We repurposed the DddA-derived cytosine base editor to incorporate a premature stop co...

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Detalles Bibliográficos
Autores principales: Tan, Lei, Qi, Xiaolong, Kong, Weining, Jin, Jiachuan, Lu, Dan, Zhang, Xu, Wang, Yue, Wang, Siting, Dong, Wei, Shi, Xudong, Chen, Wei, Wang, Jianying, Li, Keru, Xie, Yuan, Gao, Lijuan, Guan, Feifei, Gao, Kai, Li, Chaojun, Wang, Cheng, Hu, Zhibin, Zhang, Lianfeng, Guo, Xuejiang, Shen, Bin, Ma, Yuanwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104465/
https://www.ncbi.nlm.nih.gov/pubmed/37058569
http://dx.doi.org/10.1126/sciadv.adf2695

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