IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models

Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here, we demonstrate that this abnormality is associat...

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Detalles Bibliográficos
Autores principales: Carbonaro, Marisa, Wang, Kehui, Huang, Hui, Frleta, Davor, Patel, Aditi, Pennington, Alexander, Desclaux, Mathieu, Moller-Tank, Sven, Grindley, Justin, Altarejos, Judith, Zhong, Jun, Polites, Greg, Poueymirou, William, Jaspers, Stephen, Kyratsous, Christos, Zambrowicz, Brian, Murphy, Andrew, Lin, John C., Macdonald, Lynn E., Daly, Christopher, Sleeman, Mark, Thurston, Gavin, Li, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104468/
https://www.ncbi.nlm.nih.gov/pubmed/37058568
http://dx.doi.org/10.1126/sciadv.adf4490

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