TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy

Mutations in the LMNA gene encoding Lamin A and C (Lamin A/C), major components of the nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM), but the underlying molecular mechanisms have not been fully elucidated. Here, by leveraging single-cell RNA sequencing (RNA-seq), assay f...

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Detalles Bibliográficos
Autores principales: Yamada, Shintaro, Ko, Toshiyuki, Ito, Masamichi, Sassa, Tatsuro, Nomura, Seitaro, Okuma, Hiromichi, Sato, Mayuko, Imasaki, Tsuyoshi, Kikkawa, Satoshi, Zhang, Bo, Yamada, Takanobu, Seki, Yuka, Fujita, Kanna, Katoh, Manami, Kubota, Masayuki, Hatsuse, Satoshi, Katagiri, Mikako, Hayashi, Hiromu, Hamano, Momoko, Takeda, Norifumi, Morita, Hiroyuki, Takada, Shuji, Toyoda, Masashi, Uchiyama, Masanobu, Ikeuchi, Masashi, Toyooka, Kiminori, Umezawa, Akihiro, Yamanishi, Yoshihiro, Nitta, Ryo, Aburatani, Hiroyuki, Komuro, Issei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104473/
https://www.ncbi.nlm.nih.gov/pubmed/37058558
http://dx.doi.org/10.1126/sciadv.ade7047

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