Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress

Deficiencies in mitochondrial protein import are associated with a number of diseases. However, although nonimported mitochondrial proteins are at great risk of aggregation, it remains largely unclear how their accumulation causes cell dysfunction. Here, we show that nonimported citrate synthase is...

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Detalles Bibliográficos
Autores principales: Nishio, Kazuya, Kawarasaki, Tomoyuki, Sugiura, Yuki, Matsumoto, Shunsuke, Konoshima, Ayano, Takano, Yuki, Hayashi, Mayuko, Okumura, Fumihiko, Kamura, Takumi, Mizushima, Tsunehiro, Nakatsukasa, Kunio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104474/
https://www.ncbi.nlm.nih.gov/pubmed/37058555
http://dx.doi.org/10.1126/sciadv.adf1956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104474/
https://www.ncbi.nlm.nih.gov/pubmed/37058555
http://dx.doi.org/10.1126/sciadv.adf1956

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