High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599

α-synuclein (αS) is an intrinsically disordered protein whose functional ambivalence and protein structural plasticity are iconic. Coordinated protein recruitment ensures proper vesicle dynamics at the synaptic cleft, while deregulated oligomerization on cellular membranes contributes to cell damage...

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Detalles Bibliográficos
Autores principales: Schwarz, Thomas C., Beier, Andreas, Ledolter, Karin, Gossenreiter, Thomas, Höfurthner, Theresa, Hartl, Markus, Baker, Terry S., Taylor, Richard J., Konrat, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104497/
https://www.ncbi.nlm.nih.gov/pubmed/37027427
http://dx.doi.org/10.1073/pnas.2201910120

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