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Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also a conserved feature in ALS patients and disease models, yet little is known about how activity-dependent processes regula...

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Detalles Bibliográficos
Autores principales:	Malik, Ahmed M., Wu, Josephine J., Gillies, Christie A., Doctrove, Quinlan A., Li, Xingli, Huang, Haoran, Tank, Elizabeth H. M., Shakkottai, Vikram G., Barmada, Sami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104577/ https://www.ncbi.nlm.nih.gov/pubmed/37011198 http://dx.doi.org/10.1073/pnas.2206217120

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