ETV4 Mediated Tumor‐Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer (Adv. Sci. 11/2023)

Tumor‐Associated Neutrophil In article number 2205613, Xu Chen, Tianxin Lin, and co‐workers reveal a novel mechanism of tumor‐associated neutrophil (TANs) in lymph node (LN)‐metastatic bladder cancer. ETS variant transcription factor (ETV4) enhances bladder cancer (BCa) cells‐derived chemokine C‐X‐C...

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Detalles Bibliográficos
Autores principales: Zhang, Qiang, Liu, Sen, Wang, Hongjin, Xiao, Kanghua, Lu, Junlin, Chen, Siting, Huang, Ming, Xie, Ruihui, Lin, Tianxin, Chen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104622/
http://dx.doi.org/10.1002/advs.202370065
Descripción
Sumario:Tumor‐Associated Neutrophil In article number 2205613, Xu Chen, Tianxin Lin, and co‐workers reveal a novel mechanism of tumor‐associated neutrophil (TANs) in lymph node (LN)‐metastatic bladder cancer. ETS variant transcription factor (ETV4) enhances bladder cancer (BCa) cells‐derived chemokine C‐X‐C motif ligand (CXCL)1/8 to recruit TANs, leading to the increase of vascular endothelial growth factor A (VEGFA) and matrix metalloproteinase‐9 (MMP9), and then facilitating lymphangiogenesis and LN metastasis of bladder cancer. [Image: see text]

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