Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)

Immune Engineering In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co‐workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that...

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Detalles Bibliográficos
Autores principales: McBride, David A., Kerr, Matthew D., Johnson, Wade T., Nguyen, Anders, Zoccheddu, Martina, Yao, Mina, Prideaux, Edward B., Dorn, Nicholas C., Wang, Wei, Svensson, Mattias N.D., Bottini, Nunzio, Shah, Nisarg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104625/
http://dx.doi.org/10.1002/advs.202370064
Descripción
Sumario:Immune Engineering In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co‐workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease‐protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression. [Image: see text]

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