Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)

Immune Engineering In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co‐workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that...

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Autores principales: McBride, David A., Kerr, Matthew D., Johnson, Wade T., Nguyen, Anders, Zoccheddu, Martina, Yao, Mina, Prideaux, Edward B., Dorn, Nicholas C., Wang, Wei, Svensson, Mattias N.D., Bottini, Nunzio, Shah, Nisarg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104625/
http://dx.doi.org/10.1002/advs.202370064
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author McBride, David A.
Kerr, Matthew D.
Johnson, Wade T.
Nguyen, Anders
Zoccheddu, Martina
Yao, Mina
Prideaux, Edward B.
Dorn, Nicholas C.
Wang, Wei
Svensson, Mattias N.D.
Bottini, Nunzio
Shah, Nisarg J.
author_facet McBride, David A.
Kerr, Matthew D.
Johnson, Wade T.
Nguyen, Anders
Zoccheddu, Martina
Yao, Mina
Prideaux, Edward B.
Dorn, Nicholas C.
Wang, Wei
Svensson, Mattias N.D.
Bottini, Nunzio
Shah, Nisarg J.
author_sort McBride, David A.
collection PubMed
description Immune Engineering In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co‐workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease‐protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression. [Image: see text]
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spelling pubmed-101046252023-04-15 Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023) McBride, David A. Kerr, Matthew D. Johnson, Wade T. Nguyen, Anders Zoccheddu, Martina Yao, Mina Prideaux, Edward B. Dorn, Nicholas C. Wang, Wei Svensson, Mattias N.D. Bottini, Nunzio Shah, Nisarg J. Adv Sci (Weinh) Frontispiece Immune Engineering In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co‐workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease‐protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression. [Image: see text] John Wiley and Sons Inc. 2023-04-14 /pmc/articles/PMC10104625/ http://dx.doi.org/10.1002/advs.202370064 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
McBride, David A.
Kerr, Matthew D.
Johnson, Wade T.
Nguyen, Anders
Zoccheddu, Martina
Yao, Mina
Prideaux, Edward B.
Dorn, Nicholas C.
Wang, Wei
Svensson, Mattias N.D.
Bottini, Nunzio
Shah, Nisarg J.
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)
title Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)
title_full Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)
title_fullStr Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)
title_full_unstemmed Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)
title_short Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)
title_sort immunomodulatory microparticles epigenetically modulate t cells and systemically ameliorate autoimmune arthritis (adv. sci. 11/2023)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104625/
http://dx.doi.org/10.1002/advs.202370064
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