Successful Treatment of a Case of Metallo-Beta-Lactamase-Producing Raoultella ornithinolytica Bacteremia by Antimicrobial Stewardship Team Intervention and Therapeutic Drug Monitoring-Based Amikacin Treatment

An 80-year-old woman underwent pancreatoduodenectomy. Post-operation, she experienced a fever, and a culture of blood revealed metallo-beta-lactamase-producing Raoultella ornithinolytica. For treatments with aminoglycoside antimicrobial agents, a therapeutic drug monitoring-based dosing design can l...

Descripción completa

Detalles Bibliográficos
Autores principales: Koishi, Noriko, Sasano, Hiroshi, Yoshizawa, Toshihiro, Shikuri, Mika, Matsumoto, Hiroshi, Suzuki, Mai, Fukui, Yukiko, Chonan, Masayoshi, Kimura, Toshimi, Ichida, Hirofumi, Saiura, Akio, Naito, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104729/
https://www.ncbi.nlm.nih.gov/pubmed/37065978
http://dx.doi.org/10.1155/2023/5574769
Descripción
Sumario:An 80-year-old woman underwent pancreatoduodenectomy. Post-operation, she experienced a fever, and a culture of blood revealed metallo-beta-lactamase-producing Raoultella ornithinolytica. For treatments with aminoglycoside antimicrobial agents, a therapeutic drug monitoring-based dosing design can lower the risk of adverse events and enable appropriate treatment. Key Clinical Message. When aminoglycoside antimicrobial agents are administered for MBL-producing bacteremia, prescription suggestions based on TDM by antimicrobial stewardship team can reduce the occurrence of adverse events and enable appropriate treatment.

Ejemplares similares