Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda

The success of the global polio eradication initiative is threatened by the genetic instability of the oral polio vaccine, which can result in the emergence of pathogenic vaccine-derived polioviruses following prolonged replication in the guts of individuals with primary immune deficiencies or in co...

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Detalles Bibliográficos
Autores principales: Tushabe, Phionah, Bwogi, Josephine, Eliku, James Peter, Aine, Francis, Birungi, Molly, Gaizi, Joseph, Nakabazzi, Lucy, Kabaliisa, Theopista, Turyahabwe, Irene, Namuwulya, Prossy, Nanteza, Mary Bridget, Bukenya, Henry, Kanyesigye, Christopher, Katushabe, Edson, Ampeire, Immaculate, Kisakye, Annet, Bakamutumaho, Barnabas, Byabamazima, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104764/
https://www.ncbi.nlm.nih.gov/pubmed/37059887
http://dx.doi.org/10.1007/s00705-023-05759-w
Descripción
Sumario:The success of the global polio eradication initiative is threatened by the genetic instability of the oral polio vaccine, which can result in the emergence of pathogenic vaccine-derived polioviruses following prolonged replication in the guts of individuals with primary immune deficiencies or in communities with low vaccination coverage. Through environmental surveillance, circulating vaccine-derived poliovirus type 2 was detected in Uganda in the absence of detection by acute flaccid paralysis (AFP) surveillance. This underscores the sensitivity of environmental surveillance and emphasizes its usefulness in supplementing AFP surveillance for poliovirus infections in the race towards global polio eradication.

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