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Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda
The success of the global polio eradication initiative is threatened by the genetic instability of the oral polio vaccine, which can result in the emergence of pathogenic vaccine-derived polioviruses following prolonged replication in the guts of individuals with primary immune deficiencies or in co...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Vienna
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104764/ https://www.ncbi.nlm.nih.gov/pubmed/37059887 http://dx.doi.org/10.1007/s00705-023-05759-w |
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| author | Tushabe, Phionah Bwogi, Josephine Eliku, James Peter Aine, Francis Birungi, Molly Gaizi, Joseph Nakabazzi, Lucy Kabaliisa, Theopista Turyahabwe, Irene Namuwulya, Prossy Nanteza, Mary Bridget Bukenya, Henry Kanyesigye, Christopher Katushabe, Edson Ampeire, Immaculate Kisakye, Annet Bakamutumaho, Barnabas Byabamazima, Charles R. |
| author_facet | Tushabe, Phionah Bwogi, Josephine Eliku, James Peter Aine, Francis Birungi, Molly Gaizi, Joseph Nakabazzi, Lucy Kabaliisa, Theopista Turyahabwe, Irene Namuwulya, Prossy Nanteza, Mary Bridget Bukenya, Henry Kanyesigye, Christopher Katushabe, Edson Ampeire, Immaculate Kisakye, Annet Bakamutumaho, Barnabas Byabamazima, Charles R. |
| author_sort | Tushabe, Phionah |
| collection | PubMed |
| description | The success of the global polio eradication initiative is threatened by the genetic instability of the oral polio vaccine, which can result in the emergence of pathogenic vaccine-derived polioviruses following prolonged replication in the guts of individuals with primary immune deficiencies or in communities with low vaccination coverage. Through environmental surveillance, circulating vaccine-derived poliovirus type 2 was detected in Uganda in the absence of detection by acute flaccid paralysis (AFP) surveillance. This underscores the sensitivity of environmental surveillance and emphasizes its usefulness in supplementing AFP surveillance for poliovirus infections in the race towards global polio eradication. |
| format | Online Article Text |
| id | pubmed-10104764 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Springer Vienna |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101047642023-04-16 Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda Tushabe, Phionah Bwogi, Josephine Eliku, James Peter Aine, Francis Birungi, Molly Gaizi, Joseph Nakabazzi, Lucy Kabaliisa, Theopista Turyahabwe, Irene Namuwulya, Prossy Nanteza, Mary Bridget Bukenya, Henry Kanyesigye, Christopher Katushabe, Edson Ampeire, Immaculate Kisakye, Annet Bakamutumaho, Barnabas Byabamazima, Charles R. Arch Virol Brief Report The success of the global polio eradication initiative is threatened by the genetic instability of the oral polio vaccine, which can result in the emergence of pathogenic vaccine-derived polioviruses following prolonged replication in the guts of individuals with primary immune deficiencies or in communities with low vaccination coverage. Through environmental surveillance, circulating vaccine-derived poliovirus type 2 was detected in Uganda in the absence of detection by acute flaccid paralysis (AFP) surveillance. This underscores the sensitivity of environmental surveillance and emphasizes its usefulness in supplementing AFP surveillance for poliovirus infections in the race towards global polio eradication. Springer Vienna 2023-04-15 2023 /pmc/articles/PMC10104764/ /pubmed/37059887 http://dx.doi.org/10.1007/s00705-023-05759-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Report Tushabe, Phionah Bwogi, Josephine Eliku, James Peter Aine, Francis Birungi, Molly Gaizi, Joseph Nakabazzi, Lucy Kabaliisa, Theopista Turyahabwe, Irene Namuwulya, Prossy Nanteza, Mary Bridget Bukenya, Henry Kanyesigye, Christopher Katushabe, Edson Ampeire, Immaculate Kisakye, Annet Bakamutumaho, Barnabas Byabamazima, Charles R. Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda |
| title | Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda |
| title_full | Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda |
| title_fullStr | Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda |
| title_full_unstemmed | Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda |
| title_short | Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda |
| title_sort | environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in uganda |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104764/ https://www.ncbi.nlm.nih.gov/pubmed/37059887 http://dx.doi.org/10.1007/s00705-023-05759-w |
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