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Constrained catecholamines gain β(2)AR selectivity through allosteric effects on pocket dynamics

G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to drug development. The amino acids that form the orthosteric binding pocket for epinephrine and norepinephrine in the β(1) and β(2) adrenergic receptors...

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Detalles Bibliográficos
Autores principales:	Xu, Xinyu, Shonberg, Jeremy, Kaindl, Jonas, Clark, Mary J., Stößel, Anne, Maul, Luis, Mayer, Daniel, Hübner, Harald, Hirata, Kunio, Venkatakrishnan, A. J., Dror, Ron O., Kobilka, Brian K., Sunahara, Roger K., Liu, Xiangyu, Gmeiner, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104803/ https://www.ncbi.nlm.nih.gov/pubmed/37059717 http://dx.doi.org/10.1038/s41467-023-37808-y

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