CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer

Immune checkpoint blockade (ICB) is a promising treatment strategy for colorectal cancer (CRC) patients. However, most CRC patients do not response well to ICB therapy. Increasing evidence indicates that ferroptosis plays a critical role in immunotherapy. ICB efficacy may be enhanced by inducing tum...

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Detalles Bibliográficos
Autores principales: Chen, Congcong, Yang, Yabing, Guo, Yanguan, He, Jiashuai, Chen, Zuyang, Qiu, Shenghui, Zhang, Yiran, Ding, Hui, Pan, Jinghua, Pan, Yunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104818/
https://www.ncbi.nlm.nih.gov/pubmed/37059712
http://dx.doi.org/10.1038/s41419-023-05803-2

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