A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCs

A comprehensive and precise definition of the pluripotency gene regulatory network (PGRN) is crucial for clarifying the regulatory mechanisms in embryonic stem cells (ESCs). Here, after a CRISPR/Cas9-based functional genomics screen and integrative analysis with other functional genomes, transcripto...

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Detalles Bibliográficos
Autores principales: Ruan, Yan, Wang, Jiaqi, Yu, Meng, Wang, Fengsheng, Wang, Jiangjun, Xu, Yixiao, Liu, Lianlian, Cheng, Yuda, Yang, Ran, Zhang, Chen, Yang, Yi, Wang, JiaLi, Wu, Wei, Huang, Yi, Tian, Yanping, Chen, Guangxing, Zhang, Junlei, Jian, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104827/
https://www.ncbi.nlm.nih.gov/pubmed/37059858
http://dx.doi.org/10.1038/s42003-023-04700-w

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