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Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart
For those suffering from end-stage biventricular heart failure, and where a heart transplantation is not a viable option, a Total Artificial Heart (TAH) can be used as a bridge to transplant device. The Realheart TAH is a four-chamber artificial heart that uses a positive-displacement pumping techni...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104863/ https://www.ncbi.nlm.nih.gov/pubmed/37059748 http://dx.doi.org/10.1038/s41598-023-32141-2 |
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author | Bornoff, Joseph Najar, Azad Fresiello, Libera Finocchiaro, Thomas Perkins, Ina Laura Gill, Harinderjit Cookson, Andrew N. Fraser, Katharine H. |
author_facet | Bornoff, Joseph Najar, Azad Fresiello, Libera Finocchiaro, Thomas Perkins, Ina Laura Gill, Harinderjit Cookson, Andrew N. Fraser, Katharine H. |
author_sort | Bornoff, Joseph |
collection | PubMed |
description | For those suffering from end-stage biventricular heart failure, and where a heart transplantation is not a viable option, a Total Artificial Heart (TAH) can be used as a bridge to transplant device. The Realheart TAH is a four-chamber artificial heart that uses a positive-displacement pumping technique mimicking the native heart to produce pulsatile flow governed by a pair of bileaflet mechanical heart valves. The aim of this work was to create a method for simulating haemodynamics in positive-displacement blood pumps, using computational fluid dynamics with fluid–structure interaction to eliminate the need for pre-existing in vitro valve motion data, and then use it to investigate the performance of the Realheart TAH across a range of operating conditions. The device was simulated in Ansys Fluent for five cycles at pumping rates of 60, 80, 100 and 120 bpm and at stroke lengths of 19, 21, 23 and 25 mm. The moving components of the device were discretised using an overset meshing approach, a novel blended weak–strong coupling algorithm was used between fluid and structural solvers, and a custom variable time stepping scheme was used to maximise computational efficiency and accuracy. A two-element Windkessel model approximated a physiological pressure response at the outlet. The transient outflow volume flow rate and pressure results were compared against in vitro experiments using a hybrid cardiovascular simulator and showed good agreement, with maximum root mean square errors of 15% and 5% for the flow rates and pressures respectively. Ventricular washout was simulated and showed an increase as cardiac output increased, with a maximum value of 89% after four cycles at 120 bpm 25 mm. Shear stress distribution over time was also measured, showing that no more than [Formula: see text] % of the total volume exceeded 150 Pa at a cardiac output of 7 L/min. This study showed this model to be both accurate and robust across a wide range of operating points, and will enable fast and effective future studies to be undertaken on current and future generations of the Realheart TAH. |
format | Online Article Text |
id | pubmed-10104863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101048632023-04-16 Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart Bornoff, Joseph Najar, Azad Fresiello, Libera Finocchiaro, Thomas Perkins, Ina Laura Gill, Harinderjit Cookson, Andrew N. Fraser, Katharine H. Sci Rep Article For those suffering from end-stage biventricular heart failure, and where a heart transplantation is not a viable option, a Total Artificial Heart (TAH) can be used as a bridge to transplant device. The Realheart TAH is a four-chamber artificial heart that uses a positive-displacement pumping technique mimicking the native heart to produce pulsatile flow governed by a pair of bileaflet mechanical heart valves. The aim of this work was to create a method for simulating haemodynamics in positive-displacement blood pumps, using computational fluid dynamics with fluid–structure interaction to eliminate the need for pre-existing in vitro valve motion data, and then use it to investigate the performance of the Realheart TAH across a range of operating conditions. The device was simulated in Ansys Fluent for five cycles at pumping rates of 60, 80, 100 and 120 bpm and at stroke lengths of 19, 21, 23 and 25 mm. The moving components of the device were discretised using an overset meshing approach, a novel blended weak–strong coupling algorithm was used between fluid and structural solvers, and a custom variable time stepping scheme was used to maximise computational efficiency and accuracy. A two-element Windkessel model approximated a physiological pressure response at the outlet. The transient outflow volume flow rate and pressure results were compared against in vitro experiments using a hybrid cardiovascular simulator and showed good agreement, with maximum root mean square errors of 15% and 5% for the flow rates and pressures respectively. Ventricular washout was simulated and showed an increase as cardiac output increased, with a maximum value of 89% after four cycles at 120 bpm 25 mm. Shear stress distribution over time was also measured, showing that no more than [Formula: see text] % of the total volume exceeded 150 Pa at a cardiac output of 7 L/min. This study showed this model to be both accurate and robust across a wide range of operating points, and will enable fast and effective future studies to be undertaken on current and future generations of the Realheart TAH. Nature Publishing Group UK 2023-04-14 /pmc/articles/PMC10104863/ /pubmed/37059748 http://dx.doi.org/10.1038/s41598-023-32141-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Bornoff, Joseph Najar, Azad Fresiello, Libera Finocchiaro, Thomas Perkins, Ina Laura Gill, Harinderjit Cookson, Andrew N. Fraser, Katharine H. Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart |
title | Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart |
title_full | Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart |
title_fullStr | Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart |
title_full_unstemmed | Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart |
title_short | Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart |
title_sort | fluid–structure interaction modelling of a positive-displacement total artificial heart |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104863/ https://www.ncbi.nlm.nih.gov/pubmed/37059748 http://dx.doi.org/10.1038/s41598-023-32141-2 |
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