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Lysosomal lipid peroxidation mediates immunogenic cell death

Cancer cells rely on lysosome-dependent degradation to recycle nutrients that serve their energetic and biosynthetic needs. Despite great interest in repurposing the antimalarial hydroxychloroquine as a lysosomal inhibitor in clinical oncology trials, the mechanisms by which hydroxychloroquine and o...

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Detalles Bibliográficos
Autores principales: Phadatare, Pravin, Debnath, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104885/
https://www.ncbi.nlm.nih.gov/pubmed/37066873
http://dx.doi.org/10.1172/JCI169240