Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion

Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the molecular programs in human PDAC cells that drive invasion are not well understood. Using an experimental pipeline enabling PDAC organoid isolation and collection based on invasive phenotype, we assessed the transcr...

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Detalles Bibliográficos
Autores principales: Jeong, Yea Ji, Knutsdottir, Hildur, Shojaeian, Fatemeh, Lerner, Michael G., Wissler, Maria F., Henriet, Elodie, Ng, Tammy, Datta, Shalini, Navarro-Serer, Bernat, Chianchiano, Peter, Kinny-Köster, Benedict, Zimmerman, Jacquelyn W., Stein-O’Brien, Genevieve, Gaida, Matthias M., Eshleman, James R., Lin, Ming-Tseh, Fertig, Elana J., Ewald, Andrew J., Bader, Joel S., Wood, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104894/
https://www.ncbi.nlm.nih.gov/pubmed/36881486
http://dx.doi.org/10.1172/JCI162054

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