Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Adaptation of the islet β cell insulin-secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we have shown that nutrient-stimulated histone acetylation plays a key role in adapting insulin secretion t...

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Detalles Bibliográficos
Autores principales: Wortham, Matthew, Liu, Fenfen, Harrington, Austin R., Fleischman, Johanna Y., Wallace, Martina, Mulas, Francesca, Mallick, Medhavi, Vinckier, Nicholas K., Cross, Benjamin R., Chiou, Joshua, Patel, Nisha A., Sui, Yinghui, McGrail, Carolyn, Jun, Yesl, Wang, Gaowei, Jhala, Ulupi S., Schüle, Roland, Shirihai, Orian S., Huising, Mark O., Gaulton, Kyle J., Metallo, Christian M., Sander, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104905/
https://www.ncbi.nlm.nih.gov/pubmed/36821378
http://dx.doi.org/10.1172/JCI165208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104905/
https://www.ncbi.nlm.nih.gov/pubmed/36821378
http://dx.doi.org/10.1172/JCI165208

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