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Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided i...

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Autores principales: Shosha, Hadeer M., Ebaid, Hala M., Toraih, Eman A., Abdelrazek, Heba M. A., Elrayess, Ranwa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104942/
https://www.ncbi.nlm.nih.gov/pubmed/36787072
http://dx.doi.org/10.1007/s11356-023-25661-x
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author Shosha, Hadeer M.
Ebaid, Hala M.
Toraih, Eman A.
Abdelrazek, Heba M. A.
Elrayess, Ranwa A.
author_facet Shosha, Hadeer M.
Ebaid, Hala M.
Toraih, Eman A.
Abdelrazek, Heba M. A.
Elrayess, Ranwa A.
author_sort Shosha, Hadeer M.
collection PubMed
description Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided into three groups (ten/each). The control group (G1) gavaged distilled water only, low-dose treated group (G2) gavaged 3 g/kg MSG, and high-dose treated group (G3) gavaged 6 g/kg MSG from 1st to 18th days of gestation, and all pregnant rats were sacrificed on the 19th day of gestation. The effect of MSG on fetal weights, crown vertebral length (CVL), placental weight, placental ghrelin expression, and fetal skeleton examination were estimated. MSG induced a significant decrease in fetal weights, CVL lengths, placental weight, and ghrelin expression in both treatment groups compared to the control group. Several parts of the fetal skeleton showed incomplete ossification and delayed chondrification in which high-dose maternally treated fetuses were more affected. Many degenerative changes were detected in both maternal and fetal liver and kidney tissues in MSG-treated groups. Moreover, MSG caused a significant increase in serum ALT, ALP, and creatinine levels in pregnant rats’ blood. Serum progesterone was only elevated in G3 on the 19th day of gestation. This study showed that the administration of MSG during pregnancy adversely influences fetal growth and skeletal development and caused several biochemical and histological changes in the maternal and fetal liver and kidney tissues which assure the toxic and teratogenic effects of MSG.
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spelling pubmed-101049422023-04-16 Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats Shosha, Hadeer M. Ebaid, Hala M. Toraih, Eman A. Abdelrazek, Heba M. A. Elrayess, Ranwa A. Environ Sci Pollut Res Int Research Article Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided into three groups (ten/each). The control group (G1) gavaged distilled water only, low-dose treated group (G2) gavaged 3 g/kg MSG, and high-dose treated group (G3) gavaged 6 g/kg MSG from 1st to 18th days of gestation, and all pregnant rats were sacrificed on the 19th day of gestation. The effect of MSG on fetal weights, crown vertebral length (CVL), placental weight, placental ghrelin expression, and fetal skeleton examination were estimated. MSG induced a significant decrease in fetal weights, CVL lengths, placental weight, and ghrelin expression in both treatment groups compared to the control group. Several parts of the fetal skeleton showed incomplete ossification and delayed chondrification in which high-dose maternally treated fetuses were more affected. Many degenerative changes were detected in both maternal and fetal liver and kidney tissues in MSG-treated groups. Moreover, MSG caused a significant increase in serum ALT, ALP, and creatinine levels in pregnant rats’ blood. Serum progesterone was only elevated in G3 on the 19th day of gestation. This study showed that the administration of MSG during pregnancy adversely influences fetal growth and skeletal development and caused several biochemical and histological changes in the maternal and fetal liver and kidney tissues which assure the toxic and teratogenic effects of MSG. Springer Berlin Heidelberg 2023-02-14 2023 /pmc/articles/PMC10104942/ /pubmed/36787072 http://dx.doi.org/10.1007/s11356-023-25661-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Shosha, Hadeer M.
Ebaid, Hala M.
Toraih, Eman A.
Abdelrazek, Heba M. A.
Elrayess, Ranwa A.
Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats
title Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats
title_full Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats
title_fullStr Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats
title_full_unstemmed Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats
title_short Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats
title_sort effect of monosodium glutamate on fetal development and progesterone level in pregnant wistar albino rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104942/
https://www.ncbi.nlm.nih.gov/pubmed/36787072
http://dx.doi.org/10.1007/s11356-023-25661-x
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