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Is new dengue vaccine efficacy data a relief or cause for concern?
Dengue is a major global public health problem requiring a safe and efficacious vaccine as the foundation of a comprehensive countermeasure strategy. Despite decades of attempts, the world has a single dengue vaccine licensed in numerous countries, but restrictions and conditions of its use have det...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105158/ https://www.ncbi.nlm.nih.gov/pubmed/37061527 http://dx.doi.org/10.1038/s41541-023-00658-2 |
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author | Thomas, Stephen J. |
author_facet | Thomas, Stephen J. |
author_sort | Thomas, Stephen J. |
collection | PubMed |
description | Dengue is a major global public health problem requiring a safe and efficacious vaccine as the foundation of a comprehensive countermeasure strategy. Despite decades of attempts, the world has a single dengue vaccine licensed in numerous countries, but restrictions and conditions of its use have deterred uptake. Recently, clinical efficacy data has been revealed for two additional dengue vaccine candidates and the data appears encouraging. In this perspective I discuss dengue, the complexities of dengue vaccine development, early development setbacks, and how the latest data from the field may be cause for measured optimism. Finally, I provide some perspectives on evaluating dengue vaccine performance and how the pursuit of the perfect dengue vaccine may prevent advancement of vaccines which are good enough. |
format | Online Article Text |
id | pubmed-10105158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101051582023-04-17 Is new dengue vaccine efficacy data a relief or cause for concern? Thomas, Stephen J. NPJ Vaccines Perspective Dengue is a major global public health problem requiring a safe and efficacious vaccine as the foundation of a comprehensive countermeasure strategy. Despite decades of attempts, the world has a single dengue vaccine licensed in numerous countries, but restrictions and conditions of its use have deterred uptake. Recently, clinical efficacy data has been revealed for two additional dengue vaccine candidates and the data appears encouraging. In this perspective I discuss dengue, the complexities of dengue vaccine development, early development setbacks, and how the latest data from the field may be cause for measured optimism. Finally, I provide some perspectives on evaluating dengue vaccine performance and how the pursuit of the perfect dengue vaccine may prevent advancement of vaccines which are good enough. Nature Publishing Group UK 2023-04-15 /pmc/articles/PMC10105158/ /pubmed/37061527 http://dx.doi.org/10.1038/s41541-023-00658-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Perspective Thomas, Stephen J. Is new dengue vaccine efficacy data a relief or cause for concern? |
title | Is new dengue vaccine efficacy data a relief or cause for concern? |
title_full | Is new dengue vaccine efficacy data a relief or cause for concern? |
title_fullStr | Is new dengue vaccine efficacy data a relief or cause for concern? |
title_full_unstemmed | Is new dengue vaccine efficacy data a relief or cause for concern? |
title_short | Is new dengue vaccine efficacy data a relief or cause for concern? |
title_sort | is new dengue vaccine efficacy data a relief or cause for concern? |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105158/ https://www.ncbi.nlm.nih.gov/pubmed/37061527 http://dx.doi.org/10.1038/s41541-023-00658-2 |
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