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Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea

IMPORTANCE: Although couples may share many risk factors for depressive disorders in their lifetime, whether these factors mediate the shared risk of depressive disorders has rarely been investigated. OBJECTIVES: To identify the shared risk factors for depressive disorder in couples and investigate...

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Autores principales: Han, Ji Won, Yang, Hee Won, Bae, Jong Bin, Oh, Dae Jong, Moon, Dong Gyu, Lim, Eunji, Shin, Jin, Kim, Bong Jo, Lee, Dong Woo, Kim, Jeong Lan, Jhoo, Jin Hyeong, Park, Joon Hyuk, Lee, Jung Jae, Kwak, Kyung Phil, Lee, Seok Bum, Moon, Seok Woo, Ryu, Seung-Ho, Kim, Shin Gyeom, Kim, Ki Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105310/
https://www.ncbi.nlm.nih.gov/pubmed/37058304
http://dx.doi.org/10.1001/jamanetworkopen.2023.8263
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author Han, Ji Won
Yang, Hee Won
Bae, Jong Bin
Oh, Dae Jong
Moon, Dong Gyu
Lim, Eunji
Shin, Jin
Kim, Bong Jo
Lee, Dong Woo
Kim, Jeong Lan
Jhoo, Jin Hyeong
Park, Joon Hyuk
Lee, Jung Jae
Kwak, Kyung Phil
Lee, Seok Bum
Moon, Seok Woo
Ryu, Seung-Ho
Kim, Shin Gyeom
Kim, Ki Woong
author_facet Han, Ji Won
Yang, Hee Won
Bae, Jong Bin
Oh, Dae Jong
Moon, Dong Gyu
Lim, Eunji
Shin, Jin
Kim, Bong Jo
Lee, Dong Woo
Kim, Jeong Lan
Jhoo, Jin Hyeong
Park, Joon Hyuk
Lee, Jung Jae
Kwak, Kyung Phil
Lee, Seok Bum
Moon, Seok Woo
Ryu, Seung-Ho
Kim, Shin Gyeom
Kim, Ki Woong
author_sort Han, Ji Won
collection PubMed
description IMPORTANCE: Although couples may share many risk factors for depressive disorders in their lifetime, whether these factors mediate the shared risk of depressive disorders has rarely been investigated. OBJECTIVES: To identify the shared risk factors for depressive disorder in couples and investigate their mediating roles in the shared risk of depressive disorders among older adult couples. DESIGN, SETTING, AND PARTICIPANTS: This nationwide, multicenter, community-based cohort study assessed 956 older adults from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) and a cohort of their spouses (KLOSCAD-S) between January 1, 2019, to February 28, 2021. EXPOSURES: Depressive disorders of the KLOSCAD participants. MAIN OUTCOMES AND MEASURES: The mediating roles of shared factors in couples on the association between one spouse’s depressive disorder and the other’s risk of depressive disorders was examined using structural equation modeling. RESULTS: A total of 956 KLOSCAD participants (385 women [40.3%] and 571 men [59.7%]; mean [SD] age, 75.1 [5.0] years) and their spouses (571 women [59.7%] and 385 men [40.3%]; mean [SD] age, 73.9 [6.1] years) were included. The depressive disorders of the KLOSCAD participants were associated with an almost 4-fold higher risk of depressive disorders in their spouses in the KLOSCAD-S cohort (odds ratio, 3.89; 95% CI, 2.06-7.19; P < .001). Social-emotional support mediated the association between depressive disorders in the KLOSCAD participants and their spouses’ risk of depressive disorders by itself (β = 0.012; 95% CI, 0.001-0.024; P = .04; mediation proportion [MP] = 6.1%) and through chronic illness burden (β = 0.003; 95% CI, 0.000-0.006; P = .04; MP = 1.5%). Chronic medical illness burden (β = 0.025; 95% CI, 0.001-0.050; P = .04; MP = 12.6%) and presence of a cognitive disorder (β = 0.027; 95% CI, 0.003-0.051; P = .03; MP = 13.6%) mediated the association. CONCLUSIONS AND RELEVANCE: The risk factors shared by older adult couples may mediate approximately one-third of the spousal risk of depressive disorders. Identification of and intervention in the shared risk factors of depression among older adult couples may reduce the risk of depressive disorders in the spouses of older adults with depression.
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spelling pubmed-101053102023-04-16 Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea Han, Ji Won Yang, Hee Won Bae, Jong Bin Oh, Dae Jong Moon, Dong Gyu Lim, Eunji Shin, Jin Kim, Bong Jo Lee, Dong Woo Kim, Jeong Lan Jhoo, Jin Hyeong Park, Joon Hyuk Lee, Jung Jae Kwak, Kyung Phil Lee, Seok Bum Moon, Seok Woo Ryu, Seung-Ho Kim, Shin Gyeom Kim, Ki Woong JAMA Netw Open Original Investigation IMPORTANCE: Although couples may share many risk factors for depressive disorders in their lifetime, whether these factors mediate the shared risk of depressive disorders has rarely been investigated. OBJECTIVES: To identify the shared risk factors for depressive disorder in couples and investigate their mediating roles in the shared risk of depressive disorders among older adult couples. DESIGN, SETTING, AND PARTICIPANTS: This nationwide, multicenter, community-based cohort study assessed 956 older adults from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) and a cohort of their spouses (KLOSCAD-S) between January 1, 2019, to February 28, 2021. EXPOSURES: Depressive disorders of the KLOSCAD participants. MAIN OUTCOMES AND MEASURES: The mediating roles of shared factors in couples on the association between one spouse’s depressive disorder and the other’s risk of depressive disorders was examined using structural equation modeling. RESULTS: A total of 956 KLOSCAD participants (385 women [40.3%] and 571 men [59.7%]; mean [SD] age, 75.1 [5.0] years) and their spouses (571 women [59.7%] and 385 men [40.3%]; mean [SD] age, 73.9 [6.1] years) were included. The depressive disorders of the KLOSCAD participants were associated with an almost 4-fold higher risk of depressive disorders in their spouses in the KLOSCAD-S cohort (odds ratio, 3.89; 95% CI, 2.06-7.19; P < .001). Social-emotional support mediated the association between depressive disorders in the KLOSCAD participants and their spouses’ risk of depressive disorders by itself (β = 0.012; 95% CI, 0.001-0.024; P = .04; mediation proportion [MP] = 6.1%) and through chronic illness burden (β = 0.003; 95% CI, 0.000-0.006; P = .04; MP = 1.5%). Chronic medical illness burden (β = 0.025; 95% CI, 0.001-0.050; P = .04; MP = 12.6%) and presence of a cognitive disorder (β = 0.027; 95% CI, 0.003-0.051; P = .03; MP = 13.6%) mediated the association. CONCLUSIONS AND RELEVANCE: The risk factors shared by older adult couples may mediate approximately one-third of the spousal risk of depressive disorders. Identification of and intervention in the shared risk factors of depression among older adult couples may reduce the risk of depressive disorders in the spouses of older adults with depression. American Medical Association 2023-04-14 /pmc/articles/PMC10105310/ /pubmed/37058304 http://dx.doi.org/10.1001/jamanetworkopen.2023.8263 Text en Copyright 2023 Han JW et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Han, Ji Won
Yang, Hee Won
Bae, Jong Bin
Oh, Dae Jong
Moon, Dong Gyu
Lim, Eunji
Shin, Jin
Kim, Bong Jo
Lee, Dong Woo
Kim, Jeong Lan
Jhoo, Jin Hyeong
Park, Joon Hyuk
Lee, Jung Jae
Kwak, Kyung Phil
Lee, Seok Bum
Moon, Seok Woo
Ryu, Seung-Ho
Kim, Shin Gyeom
Kim, Ki Woong
Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea
title Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea
title_full Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea
title_fullStr Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea
title_full_unstemmed Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea
title_short Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea
title_sort shared risk factors for depressive disorder among older adult couples in korea
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105310/
https://www.ncbi.nlm.nih.gov/pubmed/37058304
http://dx.doi.org/10.1001/jamanetworkopen.2023.8263
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