Wdr5 is essential for fetal erythropoiesis and hematopoiesis

WDR5 is a highly conserved protein that performs multiple scaffolding functions in the context of chromatin. However, efforts to understand the function of WDR5 in normal tissues physiologically are quite limited so far. In our study, we explored the function of Wdr5 in erythropoiesis and hematopoie...

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Autores principales: Liu, Lulu, Fang, Yanjia, Ding, Xiaodan, Zhou, Weihua, Terranova, Remi, Zhang, Yan, Wang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105386/
https://www.ncbi.nlm.nih.gov/pubmed/37061728
http://dx.doi.org/10.1186/s40164-023-00385-3
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author Liu, Lulu
Fang, Yanjia
Ding, Xiaodan
Zhou, Weihua
Terranova, Remi
Zhang, Yan
Wang, He
author_facet Liu, Lulu
Fang, Yanjia
Ding, Xiaodan
Zhou, Weihua
Terranova, Remi
Zhang, Yan
Wang, He
author_sort Liu, Lulu
collection PubMed
description WDR5 is a highly conserved protein that performs multiple scaffolding functions in the context of chromatin. However, efforts to understand the function of WDR5 in normal tissues physiologically are quite limited so far. In our study, we explored the function of Wdr5 in erythropoiesis and hematopoiesis by using a hematopoietic-specific Wdr5 knockout mouse model. We found that loss of Wdr5 mediated by Vav-iCre leads to embryonic lethality with defective erythropoiesis. In addition, Wdr5-deficiency completely impairs the hematopoietic stem and progenitor cells function and might alter the immunophenotype of these stem cells and progenitors by decreasing c-Kit expression. Collectively, we identified the pivotal role of Wdr5 in fetal hematopoiesis and erythropoiesis as the de novo findings. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-023-00385-3.
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spelling pubmed-101053862023-04-16 Wdr5 is essential for fetal erythropoiesis and hematopoiesis Liu, Lulu Fang, Yanjia Ding, Xiaodan Zhou, Weihua Terranova, Remi Zhang, Yan Wang, He Exp Hematol Oncol Correspondence WDR5 is a highly conserved protein that performs multiple scaffolding functions in the context of chromatin. However, efforts to understand the function of WDR5 in normal tissues physiologically are quite limited so far. In our study, we explored the function of Wdr5 in erythropoiesis and hematopoiesis by using a hematopoietic-specific Wdr5 knockout mouse model. We found that loss of Wdr5 mediated by Vav-iCre leads to embryonic lethality with defective erythropoiesis. In addition, Wdr5-deficiency completely impairs the hematopoietic stem and progenitor cells function and might alter the immunophenotype of these stem cells and progenitors by decreasing c-Kit expression. Collectively, we identified the pivotal role of Wdr5 in fetal hematopoiesis and erythropoiesis as the de novo findings. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-023-00385-3. BioMed Central 2023-04-15 /pmc/articles/PMC10105386/ /pubmed/37061728 http://dx.doi.org/10.1186/s40164-023-00385-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Correspondence
Liu, Lulu
Fang, Yanjia
Ding, Xiaodan
Zhou, Weihua
Terranova, Remi
Zhang, Yan
Wang, He
Wdr5 is essential for fetal erythropoiesis and hematopoiesis
title Wdr5 is essential for fetal erythropoiesis and hematopoiesis
title_full Wdr5 is essential for fetal erythropoiesis and hematopoiesis
title_fullStr Wdr5 is essential for fetal erythropoiesis and hematopoiesis
title_full_unstemmed Wdr5 is essential for fetal erythropoiesis and hematopoiesis
title_short Wdr5 is essential for fetal erythropoiesis and hematopoiesis
title_sort wdr5 is essential for fetal erythropoiesis and hematopoiesis
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105386/
https://www.ncbi.nlm.nih.gov/pubmed/37061728
http://dx.doi.org/10.1186/s40164-023-00385-3
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