Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose

BACKGROUND: Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice we...

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Autores principales: Wang, Ya, Wang, Jiahui, Li, Hehai, Lao, Jianlong, Jia, Dan, Liu, Junlong, Wang, Jinming, Luo, Jianxun, Guan, Guiquan, Yin, Hong, Li, Youquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105457/
https://www.ncbi.nlm.nih.gov/pubmed/37061697
http://dx.doi.org/10.1186/s12866-023-02846-5
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author Wang, Ya
Wang, Jiahui
Li, Hehai
Lao, Jianlong
Jia, Dan
Liu, Junlong
Wang, Jinming
Luo, Jianxun
Guan, Guiquan
Yin, Hong
Li, Youquan
author_facet Wang, Ya
Wang, Jiahui
Li, Hehai
Lao, Jianlong
Jia, Dan
Liu, Junlong
Wang, Jinming
Luo, Jianxun
Guan, Guiquan
Yin, Hong
Li, Youquan
author_sort Wang, Ya
collection PubMed
description BACKGROUND: Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose. RESULTS: T37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver. CONCLUSIONS: T37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant.
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spelling pubmed-101054572023-04-16 Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose Wang, Ya Wang, Jiahui Li, Hehai Lao, Jianlong Jia, Dan Liu, Junlong Wang, Jinming Luo, Jianxun Guan, Guiquan Yin, Hong Li, Youquan BMC Microbiol Research BACKGROUND: Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose. RESULTS: T37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver. CONCLUSIONS: T37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant. BioMed Central 2023-04-15 /pmc/articles/PMC10105457/ /pubmed/37061697 http://dx.doi.org/10.1186/s12866-023-02846-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Ya
Wang, Jiahui
Li, Hehai
Lao, Jianlong
Jia, Dan
Liu, Junlong
Wang, Jinming
Luo, Jianxun
Guan, Guiquan
Yin, Hong
Li, Youquan
Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose
title Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose
title_full Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose
title_fullStr Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose
title_full_unstemmed Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose
title_short Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose
title_sort antioxidant effects of bifidobacterium longum t37a in mice weight loss and aging model induced by d-galactose
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105457/
https://www.ncbi.nlm.nih.gov/pubmed/37061697
http://dx.doi.org/10.1186/s12866-023-02846-5
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