Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells

BACKGROUND: Ovarian cancer has a specific unmet clinical need, with a persistently poor 5-year survival rate observed in women with advanced stage disease warranting continued efforts to develop new treatment options. The amplification of BRD4 in a significant subset of high-grade serous ovarian car...

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Detalles Bibliográficos
Autores principales: Quintela, Marcos, James, David W., Pociute, Agne, Powell, Lydia, Edwards, Kadie, Coombes, Zoe, Garcia, Jetzabel, Garton, Neil, Das, Nagindra, Lutchman-Singh, Kerryn, Margarit, Lavinia, Beynon, Amy L., Rioja, Inmaculada, Prinjha, Rab K., Harker, Nicola R., Gonzalez, Deyarina, Conlan, R. Steven, Francis, Lewis W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105475/
https://www.ncbi.nlm.nih.gov/pubmed/37060086
http://dx.doi.org/10.1186/s13148-023-01477-x

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