Cargando…

Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer

BACKGROUND: Approximately 10–20% of patients diagnosed with prostate cancer (PCa) evolve into castration-resistant prostate cancer (CRPC), while nearly 90% of patients with metastatic CRPC (mCRPC) exhibit osseous metastases (BM). These BM are intimately correlated with the stability of the tumour mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Qingfu, Zhang, Peng, Zhao, Zhongting, Wang, Jun, Zhang, Hepeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2023
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105558/ https://www.ncbi.nlm.nih.gov/pubmed/37070095 http://dx.doi.org/10.7717/peerj.15013

Ejemplares similares

Comparison of metastatic castration-resistant prostate cancer in bone with other sites: clinical characteristics, molecular features and immune status
por: Xu, Zhengquan, et al.
Publicado: (2021)

Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation
por: Huang, Lili, et al.
Publicado: (2023)

Identification of key genes and multiple molecular pathways of metastatic process in prostate cancer
por: Guo, Lihuang, et al.
Publicado: (2019)

Differential expression profile of mRNAs, lncRNAs, and circRNAs reveals potential molecular mechanism in breast cancer
por: Li, Yuan, et al.
Publicado: (2022)

Comprehensive analysis of fatty acid metabolism-related gene signatures for predicting prognosis in patients with prostate cancer
por: Wang, Hongbo, et al.
Publicado: (2023)

Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics
por: Jiang, Yan, et al.
Publicado: (2020)

Construction and validation of a fatty acid metabolism-related gene signature for predicting prognosis and therapeutic response in patients with prostate cancer
por: Zhao, Hongjun, et al.
Publicado: (2023)

Exploring the mechanism of Danggui Buxue Decoction in regulating atherosclerotic disease network based on integrated pharmacological methods
por: Xu, Hao, et al.
Publicado: (2021)

Exploring the mechanism of cordycepin combined with doxorubicin in treating glioblastoma based on network pharmacology and biological verification
por: Chen, Jing, et al.
Publicado: (2022)

Exploring the potential biomarkers for prognosis of glioblastoma via weighted gene co-expression network analysis
por: Zhang, Mengyuan, et al.
Publicado: (2022)

Identification of prognostic splicing factors and exploration of their potential regulatory mechanisms in pancreatic adenocarcinoma
por: Rong, Min-hua, et al.
Publicado: (2020)

Microarray analysis of genes with differential expression of m6A methylation in lung cancer
por: Wu, Shuo, et al.
Publicado: (2021)

Comprehensive analysis of differentially expressed microRNAs and mRNAs in MDBK cells expressing bovine papillomavirus E5 oncogene
por: Pang, Feng, et al.
Publicado: (2019)

Bioinformatics analysis and identification of circular RNAs promoting the osteogenic differentiation of human bone marrow mesenchymal stem cells on titanium treated by surface mechanical attrition
por: Zhu, Shanshan, et al.
Publicado: (2020)

Identification of differentially expressed methylated genes in melanoma versus nevi using bioinformatics methods
por: He, Congcong, et al.
Publicado: (2020)

High-dose dexamethasone injection disordered metabolism and multiple protein kinases expression in the mouse kidney
por: Zhang, Zaikuan, et al.
Publicado: (2021)

Bioinformatic analysis identifies potentially key differentially expressed genes in oncogenesis and progression of clear cell renal cell carcinoma
por: Zhang, Haiping, et al.
Publicado: (2019)

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation
por: Yan, Fei, et al.
Publicado: (2021)

Identification of immune-based prostate cancer subtypes using mRNA expression
por: Song, Jukun, et al.
Publicado: (2021)

The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma
por: Huang, Runzhi, et al.
Publicado: (2020)

Prognostic model of invasive ductal carcinoma of the breast based on differentially expressed glycolysis-related genes
por: Li, Xiaoping, et al.
Publicado: (2020)

Genome-wide identification and analysis of circular RNAs differentially expressed in the longissimus dorsi between Kazakh cattle and Xinjiang brown cattle
por: Yan, Xiang-Min, et al.
Publicado: (2020)

Cloning, phylogenetic research, and prokaryotic expression study of the metabolic detoxification gene EoGSTs1 in Empoasca onukii Matsuda
por: Zhang, Yujie, et al.
Publicado: (2019)

Expression of 5‐methylcytosine regulators is highly associated with the clinical phenotypes of prostate cancer and DNMTs expression predicts biochemical recurrence
por: Wang, Lin, et al.
Publicado: (2021)

Molecular marker development and genetic diversity exploration in Medicago polymorpha
por: Ren, Hailong, et al.
Publicado: (2023)

A model of twenty-three metabolic-related genes predicting overall survival for lung adenocarcinoma
por: Zhao, Zhenyu, et al.
Publicado: (2020)

MicroRNA panel in serum reveals novel diagnostic biomarkers for prostate cancer
por: Zhang, Shiyu, et al.
Publicado: (2021)

Immune infiltration phenotypes of prostate adenocarcinoma and their clinical implications
por: Ma, Zehua, et al.
Publicado: (2021)

Transcriptome analysis and exploration of genes involved in the biosynthesis of secoiridoids in Gentiana rhodantha
por: Zhang, Ting, et al.
Publicado: (2023)

Utilizing network pharmacology and molecular docking to explore the underlying mechanism of Guizhi Fuling Wan in treating endometriosis
por: Wang, Haoxian, et al.
Publicado: (2021)

Exploration of the molecular targets and mechanisms of suxiao xintong dropping pills for myocardial infarction by network pharmacology method
por: Chen, Daqiu, et al.
Publicado: (2021)

Construction of competing endogenous RNA interaction network as prognostic markers in metastatic melanoma
por: He, Zan, et al.
Publicado: (2021)

How to normalize metatranscriptomic count data for differential expression analysis
por: Klingenberg, Heiner, et al.
Publicado: (2017)

Regulation of HDAC11 gene expression in early myogenic differentiation
por: Li, Qiao, et al.
Publicado: (2023)

Exploring the mechanism of Radix Rhei Et Rhizome intervention in intracerebral hemorrhage based on systematic pharmacology and proteomics strategy
por: Zhu, Xiaofei, et al.
Publicado: (2021)

Exploring mechanisms of Chaihu-Shugan-San against liver fibrosis by integrated multi-omics and network pharmacology approach
por: Xie, Zhihao, et al.
Publicado: (2022)

Differentially expressed transcripts and associated protein pathways in basilar artery smooth muscle cells of the high-salt intake–induced hypertensive rat
por: Huang, Junhao, et al.
Publicado: (2020)

Analysis of ceRNA network of differentially expressed genes in FaDu cell line and a cisplatin-resistant line derived from it
por: Zhang, Gehou, et al.
Publicado: (2021)

GeNET: a web application to explore and share Gene Co-expression Network Analysis data
por: Desai, Amit P., et al.
Publicado: (2017)

Power analysis and sample size estimation for RNA-Seq differential expression
por: Ching, Travers, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_i7q31fftfg1497fd4s4d7rkdkr