Cargando…

The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity

Background: Research on employee care partners of patients with multiple sclerosis (MS) is limited. Objectives: The clinical and economic impact on employee care partners was evaluated by MS disease severity. Methods: Employees with spouses/domestic partners with MS from the Workpartners database (J...

Descripción completa

Detalles Bibliográficos
Autores principales: Hendin, Barry, Brook, Richard A., Beren, Ian A., Kleinman, Nathan, Fink, Cindy, Phillips, Amy L., Lobo, Carroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia Data Analytics, LLC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105615/
https://www.ncbi.nlm.nih.gov/pubmed/37069893
http://dx.doi.org/10.36469/001c.57593
_version_ 1785026248859189248
author Hendin, Barry
Brook, Richard A.
Beren, Ian A.
Kleinman, Nathan
Fink, Cindy
Phillips, Amy L.
Lobo, Carroline
author_facet Hendin, Barry
Brook, Richard A.
Beren, Ian A.
Kleinman, Nathan
Fink, Cindy
Phillips, Amy L.
Lobo, Carroline
author_sort Hendin, Barry
collection PubMed
description Background: Research on employee care partners of patients with multiple sclerosis (MS) is limited. Objectives: The clinical and economic impact on employee care partners was evaluated by MS disease severity. Methods: Employees with spouses/domestic partners with MS from the Workpartners database (Jan. 1, 2010–Dec. 31, 2019) were eligible if: spouse/partner had at least 3 MS-related (ICD-9-CM/ICD-10-CM:340.xx/G35) inpatient/outpatient/disease-modifying therapy claims within 1 year (latest claim = index date); 6-month pre-index/1-year post-index enrollment; and age 18 to 64 years. Employee care partners’ demographic/clinical characteristics and direct/indirect costs were compared across predetermined MS severity categories. Logistic and generalized linear regression modeled the costs. Results: Among 1041 employee care partners of patients with MS, 358 (34.4%) patients had mild MS, 491 (47.2%) moderate, and 192 (18.4%) severe. Mean (standard error [SE]) employee care partner age was 49.0 (0.5) for patients with mild disease, 50.5 (0.4) for moderate, 51.7 (0.6) for severe; percent female care partners was 24.6% [2.3%] mild, 19.8% [1.8%] moderate, 27.6% [3.2%] severe; and mean care partner Charlson Comorbidity Index scores 0.28 (0.05) mild, 0.30 (0.04) moderate, 0.27 (0.06) severe. More care partners of patients with moderate/severe vs mild MS had hyperlipidemia (32.6%/31.8% vs 21.2%), hypertension (29.5%/29.7% vs 19.3%), gastrointestinal disease (20.8%/22.9% vs 13.1%), depression (9.2%/10.9% vs 3.9%), and anxiety 10.6%/8.9% vs 4.2%). Adjusted mean medical costs were greater for employee care partners of patients with moderate vs mild/severe disease (P<.001). Pharmacy costs (SE) were lower for employee care partners of mild vs severe/moderate patients (P<.005). Sick leave costs (SE) were greater for employee care partners of mild/severe vs moderate patients (P<.05). Discussion: Employee care partners of patients with moderate/severe vs mild MS had more comorbidities (ie, hypertension, gastrointestinal disease, depression, and anxiety) and higher pharmacy costs. Employee care partners of patients with moderate vs mild/severe MS had higher medical and lower sick leave costs. Treatment strategies that improve patient outcomes may reduce employee care partner burden and lower costs for employers in some instances. Conclusions: Comorbidities and direct/indirect costs of employees whose spouses/partners have MS were considerable and varied with MS severity.
format Online
Article
Text
id pubmed-10105615
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Columbia Data Analytics, LLC
record_format MEDLINE/PubMed
spelling pubmed-101056152023-04-16 The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity Hendin, Barry Brook, Richard A. Beren, Ian A. Kleinman, Nathan Fink, Cindy Phillips, Amy L. Lobo, Carroline J Health Econ Outcomes Res Neurological Diseases Background: Research on employee care partners of patients with multiple sclerosis (MS) is limited. Objectives: The clinical and economic impact on employee care partners was evaluated by MS disease severity. Methods: Employees with spouses/domestic partners with MS from the Workpartners database (Jan. 1, 2010–Dec. 31, 2019) were eligible if: spouse/partner had at least 3 MS-related (ICD-9-CM/ICD-10-CM:340.xx/G35) inpatient/outpatient/disease-modifying therapy claims within 1 year (latest claim = index date); 6-month pre-index/1-year post-index enrollment; and age 18 to 64 years. Employee care partners’ demographic/clinical characteristics and direct/indirect costs were compared across predetermined MS severity categories. Logistic and generalized linear regression modeled the costs. Results: Among 1041 employee care partners of patients with MS, 358 (34.4%) patients had mild MS, 491 (47.2%) moderate, and 192 (18.4%) severe. Mean (standard error [SE]) employee care partner age was 49.0 (0.5) for patients with mild disease, 50.5 (0.4) for moderate, 51.7 (0.6) for severe; percent female care partners was 24.6% [2.3%] mild, 19.8% [1.8%] moderate, 27.6% [3.2%] severe; and mean care partner Charlson Comorbidity Index scores 0.28 (0.05) mild, 0.30 (0.04) moderate, 0.27 (0.06) severe. More care partners of patients with moderate/severe vs mild MS had hyperlipidemia (32.6%/31.8% vs 21.2%), hypertension (29.5%/29.7% vs 19.3%), gastrointestinal disease (20.8%/22.9% vs 13.1%), depression (9.2%/10.9% vs 3.9%), and anxiety 10.6%/8.9% vs 4.2%). Adjusted mean medical costs were greater for employee care partners of patients with moderate vs mild/severe disease (P<.001). Pharmacy costs (SE) were lower for employee care partners of mild vs severe/moderate patients (P<.005). Sick leave costs (SE) were greater for employee care partners of mild/severe vs moderate patients (P<.05). Discussion: Employee care partners of patients with moderate/severe vs mild MS had more comorbidities (ie, hypertension, gastrointestinal disease, depression, and anxiety) and higher pharmacy costs. Employee care partners of patients with moderate vs mild/severe MS had higher medical and lower sick leave costs. Treatment strategies that improve patient outcomes may reduce employee care partner burden and lower costs for employers in some instances. Conclusions: Comorbidities and direct/indirect costs of employees whose spouses/partners have MS were considerable and varied with MS severity. Columbia Data Analytics, LLC 2023-04-13 /pmc/articles/PMC10105615/ /pubmed/37069893 http://dx.doi.org/10.36469/001c.57593 Text en https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (4.0) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurological Diseases
Hendin, Barry
Brook, Richard A.
Beren, Ian A.
Kleinman, Nathan
Fink, Cindy
Phillips, Amy L.
Lobo, Carroline
The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity
title The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity
title_full The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity
title_fullStr The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity
title_full_unstemmed The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity
title_short The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity
title_sort clinical and economic impact of employees who are care partners of patients with multiple sclerosis by disease severity
topic Neurological Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105615/
https://www.ncbi.nlm.nih.gov/pubmed/37069893
http://dx.doi.org/10.36469/001c.57593
work_keys_str_mv AT hendinbarry theclinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT brookricharda theclinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT bereniana theclinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT kleinmannathan theclinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT finkcindy theclinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT phillipsamyl theclinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT lobocarroline theclinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT hendinbarry clinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT brookricharda clinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT bereniana clinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT kleinmannathan clinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT finkcindy clinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT phillipsamyl clinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity
AT lobocarroline clinicalandeconomicimpactofemployeeswhoarecarepartnersofpatientswithmultiplesclerosisbydiseaseseverity