Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25

Carbapenem-resistant Enterobacterales, including KPC-producing Klebsiella pneumoniae, represent a major threat to public health due to their rapid spread. The beta-lactam/beta-lactamase inhibitor (BL/BLI) combination ceftazidime-avibactam (CAZ-AVI) has recently been introduced and shown to exhibit e...

Descripción completa

Detalles Bibliográficos
Autores principales: Findlay, Jacqueline, Poirel, Laurent, Bouvier, Maxime, Gaia, Valeria, Nordmann, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105652/
https://www.ncbi.nlm.nih.gov/pubmed/36877262
http://dx.doi.org/10.1007/s10096-023-04582-0
_version_ 1785026256030400512
author Findlay, Jacqueline
Poirel, Laurent
Bouvier, Maxime
Gaia, Valeria
Nordmann, Patrice
author_facet Findlay, Jacqueline
Poirel, Laurent
Bouvier, Maxime
Gaia, Valeria
Nordmann, Patrice
author_sort Findlay, Jacqueline
collection PubMed
description Carbapenem-resistant Enterobacterales, including KPC-producing Klebsiella pneumoniae, represent a major threat to public health due to their rapid spread. The beta-lactam/beta-lactamase inhibitor (BL/BLI) combination ceftazidime-avibactam (CAZ-AVI) has recently been introduced and shown to exhibit excellent activity toward multidrug-resistant KPC-producing Enterobacterales strains. However, CAZ-AVI-resistant K. pneumoniae isolates are being increasingly reported, mostly corresponding to producers of KPC variants that confer resistance to CAZ-AVI but at a cost of carbapenem resistance. We have characterized here, both phenotypically and genotypically, a clinical CAZ-AVI- and carbapenem-resistant KPC-2 K. pneumoniae isolate co-producing the inhibitor-resistant extended-spectrum beta-lactamase VEB-25.
format Online
Article
Text
id pubmed-10105652
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-101056522023-04-17 Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25 Findlay, Jacqueline Poirel, Laurent Bouvier, Maxime Gaia, Valeria Nordmann, Patrice Eur J Clin Microbiol Infect Dis Brief Report Carbapenem-resistant Enterobacterales, including KPC-producing Klebsiella pneumoniae, represent a major threat to public health due to their rapid spread. The beta-lactam/beta-lactamase inhibitor (BL/BLI) combination ceftazidime-avibactam (CAZ-AVI) has recently been introduced and shown to exhibit excellent activity toward multidrug-resistant KPC-producing Enterobacterales strains. However, CAZ-AVI-resistant K. pneumoniae isolates are being increasingly reported, mostly corresponding to producers of KPC variants that confer resistance to CAZ-AVI but at a cost of carbapenem resistance. We have characterized here, both phenotypically and genotypically, a clinical CAZ-AVI- and carbapenem-resistant KPC-2 K. pneumoniae isolate co-producing the inhibitor-resistant extended-spectrum beta-lactamase VEB-25. Springer Berlin Heidelberg 2023-03-06 2023 /pmc/articles/PMC10105652/ /pubmed/36877262 http://dx.doi.org/10.1007/s10096-023-04582-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Findlay, Jacqueline
Poirel, Laurent
Bouvier, Maxime
Gaia, Valeria
Nordmann, Patrice
Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
title Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
title_full Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
title_fullStr Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
title_full_unstemmed Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
title_short Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
title_sort resistance to ceftazidime-avibactam in a kpc-2–producing klebsiella pneumoniae caused by the extended-spectrum beta-lactamase veb-25
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105652/
https://www.ncbi.nlm.nih.gov/pubmed/36877262
http://dx.doi.org/10.1007/s10096-023-04582-0
work_keys_str_mv AT findlayjacqueline resistancetoceftazidimeavibactaminakpc2producingklebsiellapneumoniaecausedbytheextendedspectrumbetalactamaseveb25
AT poirellaurent resistancetoceftazidimeavibactaminakpc2producingklebsiellapneumoniaecausedbytheextendedspectrumbetalactamaseveb25
AT bouviermaxime resistancetoceftazidimeavibactaminakpc2producingklebsiellapneumoniaecausedbytheextendedspectrumbetalactamaseveb25
AT gaiavaleria resistancetoceftazidimeavibactaminakpc2producingklebsiellapneumoniaecausedbytheextendedspectrumbetalactamaseveb25
AT nordmannpatrice resistancetoceftazidimeavibactaminakpc2producingklebsiellapneumoniaecausedbytheextendedspectrumbetalactamaseveb25

Ejemplares similares