α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain

Changes in brain glucose metabolism occur in many neurological disorders as well as during aging. Most studies on the uptake of glucose in the brain use positron emission tomography, which requires injection of a radioactive tracer. Our study shows that ultra-high-field (1)H-MRS can be used to measu...

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Autores principales: Weng, Guodong, Radojewski, Piotr, Slotboom, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105689/
https://www.ncbi.nlm.nih.gov/pubmed/37061615
http://dx.doi.org/10.1038/s41598-023-33161-8
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author Weng, Guodong
Radojewski, Piotr
Slotboom, Johannes
author_facet Weng, Guodong
Radojewski, Piotr
Slotboom, Johannes
author_sort Weng, Guodong
collection PubMed
description Changes in brain glucose metabolism occur in many neurological disorders as well as during aging. Most studies on the uptake of glucose in the brain use positron emission tomography, which requires injection of a radioactive tracer. Our study shows that ultra-high-field (1)H-MRS can be used to measure α-d-glucose at 5.22 ppm in vivo, and the α-d-glucose can be used as a radiation-free tracer in the human brain.
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spelling pubmed-101056892023-04-17 α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain Weng, Guodong Radojewski, Piotr Slotboom, Johannes Sci Rep Article Changes in brain glucose metabolism occur in many neurological disorders as well as during aging. Most studies on the uptake of glucose in the brain use positron emission tomography, which requires injection of a radioactive tracer. Our study shows that ultra-high-field (1)H-MRS can be used to measure α-d-glucose at 5.22 ppm in vivo, and the α-d-glucose can be used as a radiation-free tracer in the human brain. Nature Publishing Group UK 2023-04-15 /pmc/articles/PMC10105689/ /pubmed/37061615 http://dx.doi.org/10.1038/s41598-023-33161-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Weng, Guodong
Radojewski, Piotr
Slotboom, Johannes
α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain
title α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain
title_full α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain
title_fullStr α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain
title_full_unstemmed α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain
title_short α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain
title_sort α-d-glucose as a non-radioactive mrs tracer for metabolic studies of the brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105689/
https://www.ncbi.nlm.nih.gov/pubmed/37061615
http://dx.doi.org/10.1038/s41598-023-33161-8
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