Cargando…
Functional Synthetic Biology
Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and f...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105873/ https://www.ncbi.nlm.nih.gov/pubmed/37073284 http://dx.doi.org/10.1093/synbio/ysad006 |
_version_ | 1785026304735707136 |
---|---|
author | Aldulijan, Ibrahim Beal, Jacob Billerbeck, Sonja Bouffard, Jeff Chambonnier, Gaël Ntelkis, Nikolaos Guerreiro, Isaac Holub, Martin Ross, Paul Selvarajah, Vinoo Sprent, Noah Vidal, Gonzalo Vignoni, Alejandro |
author_facet | Aldulijan, Ibrahim Beal, Jacob Billerbeck, Sonja Bouffard, Jeff Chambonnier, Gaël Ntelkis, Nikolaos Guerreiro, Isaac Holub, Martin Ross, Paul Selvarajah, Vinoo Sprent, Noah Vidal, Gonzalo Vignoni, Alejandro |
author_sort | Aldulijan, Ibrahim |
collection | PubMed |
description | Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost. |
format | Online Article Text |
id | pubmed-10105873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101058732023-04-17 Functional Synthetic Biology Aldulijan, Ibrahim Beal, Jacob Billerbeck, Sonja Bouffard, Jeff Chambonnier, Gaël Ntelkis, Nikolaos Guerreiro, Isaac Holub, Martin Ross, Paul Selvarajah, Vinoo Sprent, Noah Vidal, Gonzalo Vignoni, Alejandro Synth Biol (Oxf) Perspectives Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost. Oxford University Press 2023-04-08 /pmc/articles/PMC10105873/ /pubmed/37073284 http://dx.doi.org/10.1093/synbio/ysad006 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspectives Aldulijan, Ibrahim Beal, Jacob Billerbeck, Sonja Bouffard, Jeff Chambonnier, Gaël Ntelkis, Nikolaos Guerreiro, Isaac Holub, Martin Ross, Paul Selvarajah, Vinoo Sprent, Noah Vidal, Gonzalo Vignoni, Alejandro Functional Synthetic Biology |
title | Functional Synthetic Biology |
title_full | Functional Synthetic Biology |
title_fullStr | Functional Synthetic Biology |
title_full_unstemmed | Functional Synthetic Biology |
title_short | Functional Synthetic Biology |
title_sort | functional synthetic biology |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105873/ https://www.ncbi.nlm.nih.gov/pubmed/37073284 http://dx.doi.org/10.1093/synbio/ysad006 |
work_keys_str_mv | AT aldulijanibrahim functionalsyntheticbiology AT bealjacob functionalsyntheticbiology AT billerbecksonja functionalsyntheticbiology AT bouffardjeff functionalsyntheticbiology AT chambonniergael functionalsyntheticbiology AT ntelkisnikolaos functionalsyntheticbiology AT guerreiroisaac functionalsyntheticbiology AT holubmartin functionalsyntheticbiology AT rosspaul functionalsyntheticbiology AT selvarajahvinoo functionalsyntheticbiology AT sprentnoah functionalsyntheticbiology AT vidalgonzalo functionalsyntheticbiology AT vignonialejandro functionalsyntheticbiology |