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The interplay between androgens and the immune response in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex multifactorial etiology. As PCOS is a diagnosis of exclusion, standardized criteria have been developed for its diagnosis. The general consensus is that...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105935/ https://www.ncbi.nlm.nih.gov/pubmed/37062827 http://dx.doi.org/10.1186/s12967-023-04116-4 |
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author | Shabbir, Sania Khurram, Emaan Moorthi, Vedhika Sathya Eissa, Youssef Tamer Hassan Kamal, Mohammad Azhar Butler, Alexandra E. |
author_facet | Shabbir, Sania Khurram, Emaan Moorthi, Vedhika Sathya Eissa, Youssef Tamer Hassan Kamal, Mohammad Azhar Butler, Alexandra E. |
author_sort | Shabbir, Sania |
collection | PubMed |
description | Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex multifactorial etiology. As PCOS is a diagnosis of exclusion, standardized criteria have been developed for its diagnosis. The general consensus is that hyperandrogenism is the primary feature of PCOS and is associated with an array of physiological dysfunctions; excess androgens, for example, have been correlated with cytokine hypersecretion, adipocyte proliferation, and signaling pathway dysregulation. Another key feature of PCOS is insulin resistance, resulting in aberrant glucose and fatty acid metabolism. Additionally, the immune system plays a key role in PCOS. Hyperandrogenism stimulates some immune cells while it inhibits others, thereby disrupting the normal balance of immune cells and creating a state of chronic inflammation. This low-grade inflammation could contribute to infertility since it induces ovarian dysfunction. This dysregulated immune response in PCOS exhibits autoimmunity characteristics that require further investigation. This review paper examines the relationship between androgens and the immune response and how their malfunction contributes to PCOS. |
format | Online Article Text |
id | pubmed-10105935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101059352023-04-17 The interplay between androgens and the immune response in polycystic ovary syndrome Shabbir, Sania Khurram, Emaan Moorthi, Vedhika Sathya Eissa, Youssef Tamer Hassan Kamal, Mohammad Azhar Butler, Alexandra E. J Transl Med Review Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex multifactorial etiology. As PCOS is a diagnosis of exclusion, standardized criteria have been developed for its diagnosis. The general consensus is that hyperandrogenism is the primary feature of PCOS and is associated with an array of physiological dysfunctions; excess androgens, for example, have been correlated with cytokine hypersecretion, adipocyte proliferation, and signaling pathway dysregulation. Another key feature of PCOS is insulin resistance, resulting in aberrant glucose and fatty acid metabolism. Additionally, the immune system plays a key role in PCOS. Hyperandrogenism stimulates some immune cells while it inhibits others, thereby disrupting the normal balance of immune cells and creating a state of chronic inflammation. This low-grade inflammation could contribute to infertility since it induces ovarian dysfunction. This dysregulated immune response in PCOS exhibits autoimmunity characteristics that require further investigation. This review paper examines the relationship between androgens and the immune response and how their malfunction contributes to PCOS. BioMed Central 2023-04-16 /pmc/articles/PMC10105935/ /pubmed/37062827 http://dx.doi.org/10.1186/s12967-023-04116-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Shabbir, Sania Khurram, Emaan Moorthi, Vedhika Sathya Eissa, Youssef Tamer Hassan Kamal, Mohammad Azhar Butler, Alexandra E. The interplay between androgens and the immune response in polycystic ovary syndrome |
title | The interplay between androgens and the immune response in polycystic ovary syndrome |
title_full | The interplay between androgens and the immune response in polycystic ovary syndrome |
title_fullStr | The interplay between androgens and the immune response in polycystic ovary syndrome |
title_full_unstemmed | The interplay between androgens and the immune response in polycystic ovary syndrome |
title_short | The interplay between androgens and the immune response in polycystic ovary syndrome |
title_sort | interplay between androgens and the immune response in polycystic ovary syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105935/ https://www.ncbi.nlm.nih.gov/pubmed/37062827 http://dx.doi.org/10.1186/s12967-023-04116-4 |
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