Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture

This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid–liquid equilibration and the spectrophotometry method was employed for solubility measurement. Solubility and...

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Autores principales: Radmand, Samira, Rezaei, Homa, Zhao, Hongkun, Rahimpour, Elaheh, Jouyban, Abolghasem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105955/
https://www.ncbi.nlm.nih.gov/pubmed/37061696
http://dx.doi.org/10.1186/s13065-023-00950-1
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author Radmand, Samira
Rezaei, Homa
Zhao, Hongkun
Rahimpour, Elaheh
Jouyban, Abolghasem
author_facet Radmand, Samira
Rezaei, Homa
Zhao, Hongkun
Rahimpour, Elaheh
Jouyban, Abolghasem
author_sort Radmand, Samira
collection PubMed
description This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid–liquid equilibration and the spectrophotometry method was employed for solubility measurement. Solubility and density of deferiprone in non-aqueous mixtures of propylene glycol and ethanol were measured in the temperatures 293.2–313.2 K. Some equations including van’t Hoff, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff, the mixture response surface and modified Wilson equations were used for the mathematical data modeling. The apparent thermodynamic parameters of the deferiprone dissolution process were computed and reported.
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spelling pubmed-101059552023-04-17 Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture Radmand, Samira Rezaei, Homa Zhao, Hongkun Rahimpour, Elaheh Jouyban, Abolghasem BMC Chem Research This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid–liquid equilibration and the spectrophotometry method was employed for solubility measurement. Solubility and density of deferiprone in non-aqueous mixtures of propylene glycol and ethanol were measured in the temperatures 293.2–313.2 K. Some equations including van’t Hoff, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff, the mixture response surface and modified Wilson equations were used for the mathematical data modeling. The apparent thermodynamic parameters of the deferiprone dissolution process were computed and reported. Springer International Publishing 2023-04-15 /pmc/articles/PMC10105955/ /pubmed/37061696 http://dx.doi.org/10.1186/s13065-023-00950-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Radmand, Samira
Rezaei, Homa
Zhao, Hongkun
Rahimpour, Elaheh
Jouyban, Abolghasem
Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture
title Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture
title_full Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture
title_fullStr Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture
title_full_unstemmed Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture
title_short Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture
title_sort solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105955/
https://www.ncbi.nlm.nih.gov/pubmed/37061696
http://dx.doi.org/10.1186/s13065-023-00950-1
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AT rezaeihoma solubilityandthermodynamicstudyofdeferiproneinpropyleneglycolandethanolmixture
AT zhaohongkun solubilityandthermodynamicstudyofdeferiproneinpropyleneglycolandethanolmixture
AT rahimpourelaheh solubilityandthermodynamicstudyofdeferiproneinpropyleneglycolandethanolmixture
AT jouybanabolghasem solubilityandthermodynamicstudyofdeferiproneinpropyleneglycolandethanolmixture

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