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Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis
OBJECTIVE: Severe acute kidney injury (sAKI) has been associated with a higher mortality in trauma patients, and severity of trauma often correlates with risk of sAKI. Whether minor to moderate trauma is associated with sAKI is less clear. The purpose of the study was to examine the outcomes of mino...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106047/ https://www.ncbi.nlm.nih.gov/pubmed/37073335 http://dx.doi.org/10.1136/tsaco-2022-001057 |
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author | Ahmed, Nasim Kuo, Yen-Hong Mathew, Roy O Asif, Arif |
author_facet | Ahmed, Nasim Kuo, Yen-Hong Mathew, Roy O Asif, Arif |
author_sort | Ahmed, Nasim |
collection | PubMed |
description | OBJECTIVE: Severe acute kidney injury (sAKI) has been associated with a higher mortality in trauma patients, and severity of trauma often correlates with risk of sAKI. Whether minor to moderate trauma is associated with sAKI is less clear. The purpose of the study was to examine the outcomes of minor to moderate trauma patients who developed sAKI. METHODS: The National Trauma Database participant use files of 2017 and 2018 were accessed for the study. All patients aged 18 years old and above who sustained an Injury Severity Score (ISS) of <16 and who were brought to a level I or level II trauma center were included in the study. sAKI was defined as an abrupt decrease in kidney function either three times increase in serum creatinine (SCr) level from the baseline or increase in SCr to ≥4.0 mg/dL (≥353.6 µmol/L), initiation of renal replacement therapy, or anuria for ≥12 hours. Propensity matching analysis was performed between the groups who developed sAKI and without sAKI. Outcome of interest was in-hospital mortality. RESULTS: A total of 655 872 patients fulfilled the inclusion criteria with complete information, of which 1896 patients were found to have sAKI. There were significant differences between the two groups on baseline characteristics. The propensity score matching eliminated all the differences and created 1896 pairs of patients. The median hospital length of stay was longer in patients with sAKI when compared with patients who did not develop sAKI (14 (13 to 15) vs. 5 (5 to 5), days p<0.001). The overall in-hospital mortality was 20.6% in patients with sAKI compared with 2.1% without sAKI (p<0.001). CONCLUSION: The occurrence of sAKI in minor to moderate trauma patients was less than 0.5%. There was a three times longer hospital stay in patients with sAKI and 10-fold increase in mortality when compared with patients who did not develop sAKI. LEVEL OF EVIDENCE: IV. STUDY TYPE: Observational cohort study. |
format | Online Article Text |
id | pubmed-10106047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-101060472023-04-17 Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis Ahmed, Nasim Kuo, Yen-Hong Mathew, Roy O Asif, Arif Trauma Surg Acute Care Open Original Research OBJECTIVE: Severe acute kidney injury (sAKI) has been associated with a higher mortality in trauma patients, and severity of trauma often correlates with risk of sAKI. Whether minor to moderate trauma is associated with sAKI is less clear. The purpose of the study was to examine the outcomes of minor to moderate trauma patients who developed sAKI. METHODS: The National Trauma Database participant use files of 2017 and 2018 were accessed for the study. All patients aged 18 years old and above who sustained an Injury Severity Score (ISS) of <16 and who were brought to a level I or level II trauma center were included in the study. sAKI was defined as an abrupt decrease in kidney function either three times increase in serum creatinine (SCr) level from the baseline or increase in SCr to ≥4.0 mg/dL (≥353.6 µmol/L), initiation of renal replacement therapy, or anuria for ≥12 hours. Propensity matching analysis was performed between the groups who developed sAKI and without sAKI. Outcome of interest was in-hospital mortality. RESULTS: A total of 655 872 patients fulfilled the inclusion criteria with complete information, of which 1896 patients were found to have sAKI. There were significant differences between the two groups on baseline characteristics. The propensity score matching eliminated all the differences and created 1896 pairs of patients. The median hospital length of stay was longer in patients with sAKI when compared with patients who did not develop sAKI (14 (13 to 15) vs. 5 (5 to 5), days p<0.001). The overall in-hospital mortality was 20.6% in patients with sAKI compared with 2.1% without sAKI (p<0.001). CONCLUSION: The occurrence of sAKI in minor to moderate trauma patients was less than 0.5%. There was a three times longer hospital stay in patients with sAKI and 10-fold increase in mortality when compared with patients who did not develop sAKI. LEVEL OF EVIDENCE: IV. STUDY TYPE: Observational cohort study. BMJ Publishing Group 2023-04-12 /pmc/articles/PMC10106047/ /pubmed/37073335 http://dx.doi.org/10.1136/tsaco-2022-001057 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Ahmed, Nasim Kuo, Yen-Hong Mathew, Roy O Asif, Arif Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis |
title | Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis |
title_full | Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis |
title_fullStr | Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis |
title_full_unstemmed | Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis |
title_short | Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis |
title_sort | minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106047/ https://www.ncbi.nlm.nih.gov/pubmed/37073335 http://dx.doi.org/10.1136/tsaco-2022-001057 |
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