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Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial

BACKGROUND: Anxiety disorders are the most prevalent mental disorder in children and young people. Developing effective therapy for these children is critical to reduce mental disorders across the lifespan. The study aimed to evaluate the efficacy of combining cognitive behavioural therapy (CBT) and...

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Autores principales: Hudson, Jennifer L., McLellan, Lauren F., Eapen, Valsamma, Rapee, Ronald M., Wuthrich, Viviana, Lyneham, Heidi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106296/
https://www.ncbi.nlm.nih.gov/pubmed/34463234
http://dx.doi.org/10.1017/S0033291721003329
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author Hudson, Jennifer L.
McLellan, Lauren F.
Eapen, Valsamma
Rapee, Ronald M.
Wuthrich, Viviana
Lyneham, Heidi J.
author_facet Hudson, Jennifer L.
McLellan, Lauren F.
Eapen, Valsamma
Rapee, Ronald M.
Wuthrich, Viviana
Lyneham, Heidi J.
author_sort Hudson, Jennifer L.
collection PubMed
description BACKGROUND: Anxiety disorders are the most prevalent mental disorder in children and young people. Developing effective therapy for these children is critical to reduce mental disorders across the lifespan. The study aimed to evaluate the efficacy of combining cognitive behavioural therapy (CBT) and sertraline (SERT) in the treatment of anxiety in youth, using a double-blind randomised control trial design. METHODS: Ninety-nine youth (ages 7–15 years) with an anxiety disorder were randomly allocated to either individual (CBT) and SERT or individual CBT and pill placebo and assessed again immediately and 6 months after treatment. RESULTS: There were no significant differences between conditions in remission of primary anxiety disorder or all anxiety disorders. Furthermore, there were no significant differences in rates of change in diagnostic severity, parent-reported anxiety symptoms, child-reported anxiety symptoms or life interference due to anxiety. CONCLUSIONS: The efficacy of CBT for children and adolescents with anxiety disorders is not significantly enhanced by combination with a short-term course of anti-depressants over and above the combined effects of pill placebo.
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spelling pubmed-101062962023-04-17 Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial Hudson, Jennifer L. McLellan, Lauren F. Eapen, Valsamma Rapee, Ronald M. Wuthrich, Viviana Lyneham, Heidi J. Psychol Med Original Article BACKGROUND: Anxiety disorders are the most prevalent mental disorder in children and young people. Developing effective therapy for these children is critical to reduce mental disorders across the lifespan. The study aimed to evaluate the efficacy of combining cognitive behavioural therapy (CBT) and sertraline (SERT) in the treatment of anxiety in youth, using a double-blind randomised control trial design. METHODS: Ninety-nine youth (ages 7–15 years) with an anxiety disorder were randomly allocated to either individual (CBT) and SERT or individual CBT and pill placebo and assessed again immediately and 6 months after treatment. RESULTS: There were no significant differences between conditions in remission of primary anxiety disorder or all anxiety disorders. Furthermore, there were no significant differences in rates of change in diagnostic severity, parent-reported anxiety symptoms, child-reported anxiety symptoms or life interference due to anxiety. CONCLUSIONS: The efficacy of CBT for children and adolescents with anxiety disorders is not significantly enhanced by combination with a short-term course of anti-depressants over and above the combined effects of pill placebo. Cambridge University Press 2023-04 2021-08-31 /pmc/articles/PMC10106296/ /pubmed/34463234 http://dx.doi.org/10.1017/S0033291721003329 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Article
Hudson, Jennifer L.
McLellan, Lauren F.
Eapen, Valsamma
Rapee, Ronald M.
Wuthrich, Viviana
Lyneham, Heidi J.
Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial
title Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial
title_full Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial
title_fullStr Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial
title_full_unstemmed Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial
title_short Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial
title_sort combining cbt and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106296/
https://www.ncbi.nlm.nih.gov/pubmed/34463234
http://dx.doi.org/10.1017/S0033291721003329
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