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An overview of hyperbaric oxygen preconditioning against ischemic stroke
Ischemic stroke (IS) has become the second leading cause of morbidity and mortality worldwide, and the prevention of IS should be given high priority. Recent studies have indicated that hyperbaric oxygen preconditioning (HBO-PC) may be a protective nonpharmacological method, but its underlying mecha...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106353/ https://www.ncbi.nlm.nih.gov/pubmed/36729260 http://dx.doi.org/10.1007/s11011-023-01165-y |
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author | Wu, Xuyi You, Jiuhong Chen, Xinxin Zhou, Mei Ma, Hui Zhang, Tianle Huang, Cheng |
author_facet | Wu, Xuyi You, Jiuhong Chen, Xinxin Zhou, Mei Ma, Hui Zhang, Tianle Huang, Cheng |
author_sort | Wu, Xuyi |
collection | PubMed |
description | Ischemic stroke (IS) has become the second leading cause of morbidity and mortality worldwide, and the prevention of IS should be given high priority. Recent studies have indicated that hyperbaric oxygen preconditioning (HBO-PC) may be a protective nonpharmacological method, but its underlying mechanisms remain poorly defined. This study comprehensively reviewed the pathophysiology of IS and revealed the underlying mechanism of HBO-PC in protection against IS. The preventive effects of HBO-PC against IS may include inducing antioxidant, anti-inflammation, and anti-apoptosis capacity; activating autophagy and immune responses; upregulating heat shock proteins, hypoxia-inducible factor-1, and erythropoietin; and exerting protective effects upon the blood-brain barrier. In addition, HBO-PC may be considered a safe and effective method to prevent IS in combination with stem cell therapy. Although the benefits of HBO-PC on IS have been widely observed in recent research, the implementation of this technique is still controversial due to regimen differences. Transferring the results to clinical application needs to be taken carefully, and screening for the optimal regimen would be a daunting task. In addition, whether we should prescribe an individualized preconditioning regimen to each stroke patient needs further exploration. |
format | Online Article Text |
id | pubmed-10106353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-101063532023-04-18 An overview of hyperbaric oxygen preconditioning against ischemic stroke Wu, Xuyi You, Jiuhong Chen, Xinxin Zhou, Mei Ma, Hui Zhang, Tianle Huang, Cheng Metab Brain Dis Review Article Ischemic stroke (IS) has become the second leading cause of morbidity and mortality worldwide, and the prevention of IS should be given high priority. Recent studies have indicated that hyperbaric oxygen preconditioning (HBO-PC) may be a protective nonpharmacological method, but its underlying mechanisms remain poorly defined. This study comprehensively reviewed the pathophysiology of IS and revealed the underlying mechanism of HBO-PC in protection against IS. The preventive effects of HBO-PC against IS may include inducing antioxidant, anti-inflammation, and anti-apoptosis capacity; activating autophagy and immune responses; upregulating heat shock proteins, hypoxia-inducible factor-1, and erythropoietin; and exerting protective effects upon the blood-brain barrier. In addition, HBO-PC may be considered a safe and effective method to prevent IS in combination with stem cell therapy. Although the benefits of HBO-PC on IS have been widely observed in recent research, the implementation of this technique is still controversial due to regimen differences. Transferring the results to clinical application needs to be taken carefully, and screening for the optimal regimen would be a daunting task. In addition, whether we should prescribe an individualized preconditioning regimen to each stroke patient needs further exploration. Springer US 2023-02-02 2023 /pmc/articles/PMC10106353/ /pubmed/36729260 http://dx.doi.org/10.1007/s11011-023-01165-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://doi.org/http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Wu, Xuyi You, Jiuhong Chen, Xinxin Zhou, Mei Ma, Hui Zhang, Tianle Huang, Cheng An overview of hyperbaric oxygen preconditioning against ischemic stroke |
title | An overview of hyperbaric oxygen preconditioning against ischemic stroke |
title_full | An overview of hyperbaric oxygen preconditioning against ischemic stroke |
title_fullStr | An overview of hyperbaric oxygen preconditioning against ischemic stroke |
title_full_unstemmed | An overview of hyperbaric oxygen preconditioning against ischemic stroke |
title_short | An overview of hyperbaric oxygen preconditioning against ischemic stroke |
title_sort | overview of hyperbaric oxygen preconditioning against ischemic stroke |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106353/ https://www.ncbi.nlm.nih.gov/pubmed/36729260 http://dx.doi.org/10.1007/s11011-023-01165-y |
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