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Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter

Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory agent were characterized before and after infusion through...

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Autores principales: Kennedy, Sonya R., Lafond, Maxime, Haworth, Kevin J., Escudero, Daniel Suarez, Ionascu, Dan, Frierson, Brion, Huang, Shaoling, Klegerman, Melvin E., Peng, Tao, McPherson, David D., Genstler, Curtis, Holland, Christy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106464/
https://www.ncbi.nlm.nih.gov/pubmed/37062767
http://dx.doi.org/10.1038/s41598-023-33164-5
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author Kennedy, Sonya R.
Lafond, Maxime
Haworth, Kevin J.
Escudero, Daniel Suarez
Ionascu, Dan
Frierson, Brion
Huang, Shaoling
Klegerman, Melvin E.
Peng, Tao
McPherson, David D.
Genstler, Curtis
Holland, Christy K.
author_facet Kennedy, Sonya R.
Lafond, Maxime
Haworth, Kevin J.
Escudero, Daniel Suarez
Ionascu, Dan
Frierson, Brion
Huang, Shaoling
Klegerman, Melvin E.
Peng, Tao
McPherson, David D.
Genstler, Curtis
Holland, Christy K.
author_sort Kennedy, Sonya R.
collection PubMed
description Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory agent were characterized before and after infusion through an EkoSonic catheter. Cavitation activity was nucleated by Definity or fibrin-targeted, drug-loaded echogenic liposomes infused and insonified with EkoSonic catheters. Passive cavitation imaging was used to quantify and map bubble activity in a flow phantom mimicking porcine arterial flow. Cavitation was sustained during 3-min infusions of Definity or echogenic liposomes along the distal 6 cm treatment zone of the catheter. Though the EkoSonic catheter was not designed specifically for cavitation nucleation, infusion of drug-loaded echogenic liposomes can be employed to trigger and sustain bubble activity for enhanced intravascular drug delivery.
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spelling pubmed-101064642023-04-18 Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter Kennedy, Sonya R. Lafond, Maxime Haworth, Kevin J. Escudero, Daniel Suarez Ionascu, Dan Frierson, Brion Huang, Shaoling Klegerman, Melvin E. Peng, Tao McPherson, David D. Genstler, Curtis Holland, Christy K. Sci Rep Article Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory agent were characterized before and after infusion through an EkoSonic catheter. Cavitation activity was nucleated by Definity or fibrin-targeted, drug-loaded echogenic liposomes infused and insonified with EkoSonic catheters. Passive cavitation imaging was used to quantify and map bubble activity in a flow phantom mimicking porcine arterial flow. Cavitation was sustained during 3-min infusions of Definity or echogenic liposomes along the distal 6 cm treatment zone of the catheter. Though the EkoSonic catheter was not designed specifically for cavitation nucleation, infusion of drug-loaded echogenic liposomes can be employed to trigger and sustain bubble activity for enhanced intravascular drug delivery. Nature Publishing Group UK 2023-04-16 /pmc/articles/PMC10106464/ /pubmed/37062767 http://dx.doi.org/10.1038/s41598-023-33164-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kennedy, Sonya R.
Lafond, Maxime
Haworth, Kevin J.
Escudero, Daniel Suarez
Ionascu, Dan
Frierson, Brion
Huang, Shaoling
Klegerman, Melvin E.
Peng, Tao
McPherson, David D.
Genstler, Curtis
Holland, Christy K.
Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter
title Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter
title_full Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter
title_fullStr Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter
title_full_unstemmed Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter
title_short Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter
title_sort initiating and imaging cavitation from infused echo contrast agents through the ekosonic catheter
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106464/
https://www.ncbi.nlm.nih.gov/pubmed/37062767
http://dx.doi.org/10.1038/s41598-023-33164-5
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