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Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea

OBJECTIVES: After the third wave of coronavirus disease 2019 (COVID-19), by mid-February 2021, approximately 0.16% of the Korean population was confirmed positive, which appeared to be among the lowest rates worldwide at that time. However, asymptomatic transmission is challenging for COVID-19 surve...

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Autores principales: Yoon, Kyuhyun, Kim, Jayeun, Peck, Kyong Ran, Kim, Hyun Soo, Lee, Hyukmin, Hwang, Yoo-Sung, Lee, Soon Young, Cho, Sung-il, Lee, Hun Jae, Kim, Yeong-gyeong, Kim, Byoungguk, Lee, June-Woo, Kim, Ah-Ra, Do, Hyeon Nam, Kim, Dong-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Epidemiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106544/
https://www.ncbi.nlm.nih.gov/pubmed/36228670
http://dx.doi.org/10.4178/epih.e2022085
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author Yoon, Kyuhyun
Kim, Jayeun
Peck, Kyong Ran
Kim, Hyun Soo
Lee, Hyukmin
Hwang, Yoo-Sung
Lee, Soon Young
Cho, Sung-il
Lee, Hun Jae
Kim, Yeong-gyeong
Kim, Byoungguk
Lee, June-Woo
Kim, Ah-Ra
Do, Hyeon Nam
Kim, Dong-Hyun
author_facet Yoon, Kyuhyun
Kim, Jayeun
Peck, Kyong Ran
Kim, Hyun Soo
Lee, Hyukmin
Hwang, Yoo-Sung
Lee, Soon Young
Cho, Sung-il
Lee, Hun Jae
Kim, Yeong-gyeong
Kim, Byoungguk
Lee, June-Woo
Kim, Ah-Ra
Do, Hyeon Nam
Kim, Dong-Hyun
author_sort Yoon, Kyuhyun
collection PubMed
description OBJECTIVES: After the third wave of coronavirus disease 2019 (COVID-19), by mid-February 2021, approximately 0.16% of the Korean population was confirmed positive, which appeared to be among the lowest rates worldwide at that time. However, asymptomatic transmission is challenging for COVID-19 surveillance. Therefore, a community-based serosurvey of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted to understand the effectiveness of Korea’s strong containment strategy. METHODS: We collected 5,002 residual sera samples from January 30 to March 3, 2021, from 265 medical facilities in Seoul, 346 in Gyeonggi Province, and 57 in Incheon. Sixty samples from tertiary institutions were excluded. We defined the sub-regions according to the addresses of the medical facilities where the specimens were collected. Elecsys Anti-SARS-CoV-2 was used for screening, and positivity was confirmed using the SARS-CoV-2 sVNT Kit. Prevalence was estimated using sampling weights and the Wilson score interval for a binomial proportion with a 95% confidence interval. RESULTS: Among the 4,942 specimens, 32 and 25 tested positive for COVID-19 in the screening and confirmatory tests, respectively. The overall crude prevalence of SARS-CoV-2 antibodies was 0.51%. The population-adjusted overall prevalence was 0.55% in women and 0.38% in men. The region-specific estimation was 0.67% and 0.30% in Gyeonggi Province and Seoul, respectively. No positive cases were detected in Incheon. CONCLUSIONS: The proportion of undetected cases in Korea remained low as of early 2021. Therefore, an infection control strategy with exhaustive tracing and widespread pre-emptive testing appears to be effective in containing community spread of COVID-19.
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spelling pubmed-101065442023-04-18 Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea Yoon, Kyuhyun Kim, Jayeun Peck, Kyong Ran Kim, Hyun Soo Lee, Hyukmin Hwang, Yoo-Sung Lee, Soon Young Cho, Sung-il Lee, Hun Jae Kim, Yeong-gyeong Kim, Byoungguk Lee, June-Woo Kim, Ah-Ra Do, Hyeon Nam Kim, Dong-Hyun Epidemiol Health COVID-19 OBJECTIVES: After the third wave of coronavirus disease 2019 (COVID-19), by mid-February 2021, approximately 0.16% of the Korean population was confirmed positive, which appeared to be among the lowest rates worldwide at that time. However, asymptomatic transmission is challenging for COVID-19 surveillance. Therefore, a community-based serosurvey of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted to understand the effectiveness of Korea’s strong containment strategy. METHODS: We collected 5,002 residual sera samples from January 30 to March 3, 2021, from 265 medical facilities in Seoul, 346 in Gyeonggi Province, and 57 in Incheon. Sixty samples from tertiary institutions were excluded. We defined the sub-regions according to the addresses of the medical facilities where the specimens were collected. Elecsys Anti-SARS-CoV-2 was used for screening, and positivity was confirmed using the SARS-CoV-2 sVNT Kit. Prevalence was estimated using sampling weights and the Wilson score interval for a binomial proportion with a 95% confidence interval. RESULTS: Among the 4,942 specimens, 32 and 25 tested positive for COVID-19 in the screening and confirmatory tests, respectively. The overall crude prevalence of SARS-CoV-2 antibodies was 0.51%. The population-adjusted overall prevalence was 0.55% in women and 0.38% in men. The region-specific estimation was 0.67% and 0.30% in Gyeonggi Province and Seoul, respectively. No positive cases were detected in Incheon. CONCLUSIONS: The proportion of undetected cases in Korea remained low as of early 2021. Therefore, an infection control strategy with exhaustive tracing and widespread pre-emptive testing appears to be effective in containing community spread of COVID-19. Korean Society of Epidemiology 2022-09-30 /pmc/articles/PMC10106544/ /pubmed/36228670 http://dx.doi.org/10.4178/epih.e2022085 Text en © 2022, Korean Society of Epidemiology https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle COVID-19
Yoon, Kyuhyun
Kim, Jayeun
Peck, Kyong Ran
Kim, Hyun Soo
Lee, Hyukmin
Hwang, Yoo-Sung
Lee, Soon Young
Cho, Sung-il
Lee, Hun Jae
Kim, Yeong-gyeong
Kim, Byoungguk
Lee, June-Woo
Kim, Ah-Ra
Do, Hyeon Nam
Kim, Dong-Hyun
Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea
title Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea
title_full Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea
title_fullStr Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea
title_full_unstemmed Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea
title_short Seroprevalence of SARS-CoV-2 antibodies during the third wave of COVID-19 in the Seoul metropolitan area of Korea
title_sort seroprevalence of sars-cov-2 antibodies during the third wave of covid-19 in the seoul metropolitan area of korea
topic COVID-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106544/
https://www.ncbi.nlm.nih.gov/pubmed/36228670
http://dx.doi.org/10.4178/epih.e2022085
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