Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report

Although epidermoid cysts are frequently seen as benign lesions, they are highly uncommon to develop into cancerous lesions. A 36-year-old man with a cystic mass present on his left flank since childhood presented to our department. Based on the patient’s medical history and abdominal computed tomog...

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Autores principales: Choi, Woosuk, Park, Joseph Kyu-hyung, Song, Seung Geun, Kim, Baek-kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106615/
https://www.ncbi.nlm.nih.gov/pubmed/37077824
http://dx.doi.org/10.3389/fonc.2023.1017624
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author Choi, Woosuk
Park, Joseph Kyu-hyung
Song, Seung Geun
Kim, Baek-kyu
author_facet Choi, Woosuk
Park, Joseph Kyu-hyung
Song, Seung Geun
Kim, Baek-kyu
author_sort Choi, Woosuk
collection PubMed
description Although epidermoid cysts are frequently seen as benign lesions, they are highly uncommon to develop into cancerous lesions. A 36-year-old man with a cystic mass present on his left flank since childhood presented to our department. Based on the patient’s medical history and abdominal computed tomography scan, we excised the lesion under the suspicion of an epidermoid cyst. Histopathological evaluation revealed the presence of poorly differentiated carcinoma with squamoid and basaloid differentiation, which showed a strong possibility of carcinoma arising from an epidermal cyst. Next-generation sequencing using TruSight oncology 500 assay showed copy number variation of ATM and CHEK1 genes.
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spelling pubmed-101066152023-04-18 Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report Choi, Woosuk Park, Joseph Kyu-hyung Song, Seung Geun Kim, Baek-kyu Front Oncol Oncology Although epidermoid cysts are frequently seen as benign lesions, they are highly uncommon to develop into cancerous lesions. A 36-year-old man with a cystic mass present on his left flank since childhood presented to our department. Based on the patient’s medical history and abdominal computed tomography scan, we excised the lesion under the suspicion of an epidermoid cyst. Histopathological evaluation revealed the presence of poorly differentiated carcinoma with squamoid and basaloid differentiation, which showed a strong possibility of carcinoma arising from an epidermal cyst. Next-generation sequencing using TruSight oncology 500 assay showed copy number variation of ATM and CHEK1 genes. Frontiers Media S.A. 2023-04-03 /pmc/articles/PMC10106615/ /pubmed/37077824 http://dx.doi.org/10.3389/fonc.2023.1017624 Text en Copyright © 2023 Choi, Park, Song and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Choi, Woosuk
Park, Joseph Kyu-hyung
Song, Seung Geun
Kim, Baek-kyu
Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report
title Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report
title_full Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report
title_fullStr Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report
title_full_unstemmed Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report
title_short Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: A case report
title_sort next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106615/
https://www.ncbi.nlm.nih.gov/pubmed/37077824
http://dx.doi.org/10.3389/fonc.2023.1017624
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