Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas

Immune Checkpoint Therapies (ICT) have revolutionized the treatment of metastatic melanoma. However, only a subset of patients reaches complete responses. Deficient β2-microglobulin (β2M) expression impacts antigen presentation to T cells, leading to ICT resistance. Here, we investigate alternative...

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Detalles Bibliográficos
Autores principales: Wang, Mona Meng, Koskela, Saara A., Mehmood, Arfa, Langguth, Miriam, Maranou, Eleftheria, Figueiredo, Carlos R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106630/
https://www.ncbi.nlm.nih.gov/pubmed/37077920
http://dx.doi.org/10.3389/fimmu.2023.1152228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106630/
https://www.ncbi.nlm.nih.gov/pubmed/37077920
http://dx.doi.org/10.3389/fimmu.2023.1152228

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