Long COVID: Is there a kidney link?

Metabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been systematically or routinely investigated in Long COVID. Here we discuss the biochemistry of renal tubular in...

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Detalles Bibliográficos
Autores principales: Garrett, Raymond E., Palacio, Carlos H., Bar-Or, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106649/
https://www.ncbi.nlm.nih.gov/pubmed/37077670
http://dx.doi.org/10.3389/fmed.2023.1138644
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author Garrett, Raymond E.
Palacio, Carlos H.
Bar-Or, David
author_facet Garrett, Raymond E.
Palacio, Carlos H.
Bar-Or, David
author_sort Garrett, Raymond E.
collection PubMed
description Metabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been systematically or routinely investigated in Long COVID. Here we discuss the biochemistry of renal tubular injury as it may contribute to Long COVID symptoms. We propose three potential mechanisms that could be involved in Long COVID namely creatine phosphate metabolism, un-reclaimed glomerular filtrate and COVID specific proximal tubule cells (PTC) injury-a tryptophan paradigm. This approach is intended to allow for improved diagnostics and therapy for the long-haul sufferers.
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spelling pubmed-101066492023-04-18 Long COVID: Is there a kidney link? Garrett, Raymond E. Palacio, Carlos H. Bar-Or, David Front Med (Lausanne) Medicine Metabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been systematically or routinely investigated in Long COVID. Here we discuss the biochemistry of renal tubular injury as it may contribute to Long COVID symptoms. We propose three potential mechanisms that could be involved in Long COVID namely creatine phosphate metabolism, un-reclaimed glomerular filtrate and COVID specific proximal tubule cells (PTC) injury-a tryptophan paradigm. This approach is intended to allow for improved diagnostics and therapy for the long-haul sufferers. Frontiers Media S.A. 2023-04-03 /pmc/articles/PMC10106649/ /pubmed/37077670 http://dx.doi.org/10.3389/fmed.2023.1138644 Text en Copyright © 2023 Garrett, Palacio and Bar-Or. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Garrett, Raymond E.
Palacio, Carlos H.
Bar-Or, David
Long COVID: Is there a kidney link?
title Long COVID: Is there a kidney link?
title_full Long COVID: Is there a kidney link?
title_fullStr Long COVID: Is there a kidney link?
title_full_unstemmed Long COVID: Is there a kidney link?
title_short Long COVID: Is there a kidney link?
title_sort long covid: is there a kidney link?
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106649/
https://www.ncbi.nlm.nih.gov/pubmed/37077670
http://dx.doi.org/10.3389/fmed.2023.1138644
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